Evidence map›Paper›PMID 36259973›Full record

ArticleMicrobiology spectrum2022

Evaluation of Circulating and Archived HIV-1 Integrase Drug-Resistance Variants among Patients on Third-Line ART in Cameroon: Implications for Dolutegravir-Containing Regimens in Resource-Limited Settings.

Joseph Fokam, Ezechiel Ngoufack Jagni Semengue, Evariste Molimbou, Naomi-Karell Etame, Maria Mercedes Santoro, Désiré Takou, Leonella Mossiang, Alain Patrice Meledie, Collins Ambe Chenwi, Bouba Yagai and 22 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 7 institutions in 2 countries.

Joseph Fokam *Chantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Ezechiel Ngoufack Jagni Semengue *Chantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Evariste MolimbouChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Naomi-Karell EtameChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Maria Mercedes SantoroUniversity of Rome Tor Vergatagrid.6530.0, Rome, Italy.
Désiré TakouChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Leonella MossiangYaoundé Central Hospital, Yaoundé, Cameroun.
Alain Patrice MeledieDouala General Hospital, Douala, Cameroon.
Collins Ambe ChenwiChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Bouba YagaiChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Alex Durand NkaChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Beatrice DambayaChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Georges TetoChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Aude Christelle Ka'eChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Grâce Angong BeloumouChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Sandrine Claire Djupsa NdjeyepChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Nadine FainguemChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Aissatou AbbaChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Aurelie Minelle Ngueko KengniChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Michel Carlos Tommo TchouaketChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Nounouce Pamen BoubaFaculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroun.
Serge-Clotaire BillongFaculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroun.
Rina DjubgangDirectorate of Pharmacy, Drug and Laboratory, Ministry of Public Health, Yaoundé, Cameroun.
Edith Temgoua SaoundeCentral Technical Group, National AIDS Control Committee, Yaoundé, Cameroun.
Samuel Martin SossoChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Charles KouanfackYaoundé Central Hospital, Yaoundé, Cameroun.
Anne-Cecile Zoung-Kanyi BissekFaculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroun.
Emmanuel Eben-MoussiChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Vittorio ColizziChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Carlo-Federico PernoChantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.ORCID 0000-0002-0825-5388
Francesca Ceccherini-Silberstein *University of Rome Tor Vergatagrid.6530.0, Rome, Italy.ORCID 0000-0002-6024-5101
Alexis Ndjolo *Chantal BIYA International Reference Centre for Research on HIV/AIDS Management and Care, Yaoundé, Cameroun.
Centre International De Reference Chantal Biya · CMUniversity of Rome Tor Vergata · ITUniversité de Yaoundé I · CMCentral Hospital of Yaoundé · CMMinistry of Public Health · CMUniversité de Dschang · CMUniversity of Douala · CM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To ensure the long-term efficacy of dolutegravir (DTG), we evaluated the genotypic profile in viral reservoirs among patients on third-line (3L) antiretroviral therapy (ART) in Cameroon, according to prior exposure to raltegravir (RAL). A facility-based study was conducted from May through December 2021 among patients on 3L ART from HIV treatment centers in Yaoundé and Douala. Viral load was measured, and genotyping was performed on plasma RNA and proviral DNA. HIV-1 drug resistance mutations were interpreted using HIVdb.v9.1 and phylogeny analysis was performed using MEGA.v7, with

Indexed as

HIV InfectionsHIV IntegraseAdultCameroonDolutegravirFemaleHumansMaleMiddle AgedRaltegravir PotassiumResource-Limited SettingsDolutegravirHIV Integrasep31 integrase protein, Human immunodeficiency virus 1Raltegravir Potassiumarchived resistanceCameroondolutegravirHIV-1integrase inhibitorsraltegravirthird-line ART

Identifiers

PMID36259973
PMCPMC9769697
OpenAlexW4306795632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.