ArticleMemorias do Instituto Oswaldo Cruz2022
An updated gene regulatory network reconstruction of multidrug-resistant Pseudomonas aeruginosa CCBH4851.
Article in Memorias do Instituto Oswaldo Cruz, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 1 citations in OpenAlex.
- Analysis of anti-infective therapy in a challenging case of brainstem hemorrhage complicated with pneumonia.Heliyon · 2024Article
- Boolean model of the gene regulatory network ofFrontiers in microbiology · 2023Article
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Authors and funding
6 authors at 3 institutions in 1 country.
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Abstract
backgroundHealthcare-associated infections due to multidrug-resistant (MDR) bacteria such as Pseudomonas aeruginosa are significant public health issues worldwide. A system biology approach can help understand bacterial behaviour and provide novel ways to identify potential therapeutic targets and develop new drugs. Gene regulatory networks (GRN) are examples of in silico representation of interaction between regulatory genes and their targets.
objectivesIn this work, we update the MDR P. aeruginosa CCBH4851 GRN reconstruction and analyse and discuss its structural properties.
methodsWe based this study on the gene orthology inference methodology using the reciprocal best hit method. The P. aeruginosa CCBH4851 genome and GRN, published in 2019, and the P. aeruginosa PAO1 GRN, published in 2020, were used for this update reconstruction process.
findingsOur result is a GRN with a greater number of regulatory genes, target genes, and interactions compared to the previous networks, and its structural properties are consistent with the complexity of biological networks and the biological features of P. aeruginosa. MAIN
conclusionsHere, we present the largest and most complete version of P. aeruginosa GRN published to this date, to the best of our knowledge.
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