Evidence map›Paper›PMID 36259630›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2022

Gene expression profile suggests different mechanisms underlying sporadic and familial mesial temporal lobe epilepsy.

Claudia V Maurer-Morelli, Jaira F de Vasconcellos, Estela M Bruxel, Cristiane S Rocha, Amanda M do Canto, Helder Tedeschi, Clarissa L Yasuda, Fernando Cendes, Iscia Lopes-Cendes

Open access · greenAbstract read
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Introduction to the thematic issue: Recognition of women leaders in Science.Experimental biology and medicine (Maywood, N.J.) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Claudia V Maurer-MorelliDepartment of Translational Medicine, School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-888, Brazil.
Jaira F de VasconcellosDepartment of Translational Medicine, School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-888, Brazil.
Estela M BruxelDepartment of Translational Medicine, School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-888, Brazil.
Cristiane S RochaDepartment of Translational Medicine, School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-888, Brazil.
Amanda M do CantoDepartment of Translational Medicine, School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-888, Brazil.
Helder TedeschiDepartment of Neurology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-887, Brazil.
Clarissa L YasudaBrazilian Institute of Neuroscience and Neurotechnology (BRAINN), Campinas 13083-888, Brazil.
Fernando CendesBrazilian Institute of Neuroscience and Neurotechnology (BRAINN), Campinas 13083-888, Brazil.
Iscia Lopes-CendesDepartment of Translational Medicine, School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-888, Brazil.ORCID 0000-0002-6221-6822
Universidade Estadual de Campinas (UNICAMP) · BRJames Madison University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) have hippocampal sclerosis on the postoperative histopathological examination. Although most patients with MTLE do not refer to a family history of the disease, familial forms of MTLE have been reported. We studied surgical specimens from patients with MTLE who had epilepsy surgery for medically intractable seizures. We assessed and compared gene expression profiles of the tissue lesion found in patients with familial MTLE (

Indexed as

Epilepsy, Temporal LobeHippocampusHumansMagnetic Resonance ImagingRNA, MessengerTranscriptomeRNA, Messengerepilepsy mechanismepilepsy therapyExpression microarrayfocal epilepsygenetic epilepsyhippocampal sclerosis

Identifiers

PMID36259630
PMCPMC9899983
OpenAlexW4306787400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.