ArticleHypertension (Dallas, Tex. : 1979)2023
Peripheral Immune Cell Composition is Altered in Women Before and After a Hypertension Diagnosis.
Article in Hypertension (Dallas, Tex. : 1979), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Unveiling the Immune Mechanisms of Hypertension With Single-Cell Transcriptome-Wide Mendelian Randomization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Immune Cell Type-Specific DNA Methylation Regions Associate With 24-Hour Blood Pressure Regulation in Black People.Journal of the American Heart Association · 2026Article
- The relationship between white blood cell counts and pediatric hypertension: a prospective cohort study.Journal of human hypertension · 2026Article
- Reference Intervals for Lymphocyte Subpopulations in Healthy Chinese Han Adults: A Single-Center Study.Journal of clinical laboratory analysis · 2026Article
- 24-Hour ambulatory blood pressure and C-reactive protein: a systematic review and meta-analysis.Clinical hypertension · 2026Review
- Methylation-based biological age and cardiotoxicity risk in breast cancer patients treated with trastuzumab.Cardio-oncology (London, England) · 2025Article
- Peripheral blood lymphocyte subsets of Chinese adults with liver steatosis.Scientific reports · 2025Article
- Article
- Methylation cytometric pretreatment blood immune profiles with tumor mutation burden as prognostic indicators for survival outcomes in head and neck cancer patients on anti-PD-1 therapy.NPJ precision oncology · 2024Article
- Revisiting sex as a biological variable in hypertension research.The Journal of clinical investigation · 2024Review
- A novel method for cell deconvolution using DNA methylation in PCA space.BMC genomics · 2024Article
- methscore: a comprehensive R function for DNA methylation-based health predictors.Bioinformatics (Oxford, England) · 2024Article
- Article
- Circulating Leukocyte Subsets Before and After a Breast Cancer Diagnosis and Therapy.JAMA network open · 2024Article
- Progress towards improving blood pressure control.Nature reviews. Nephrology · 2024Article
- A link between white blood cell count and blood pressure levels.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Decreased natural killer cell activity as a potential predictor of hypertensive incidence.Frontiers in immunology · 2024Article
- Methylation-Based Biological Age and Hypertension Prevalence and Incidence.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Hypertension and severe COVID-19.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Reply to: Hypertension and severe COVID-19.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
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7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe development and consequences of hypertension involve multiple biological systems that may include changes in immune profiles. Whether hypertension is related to peripheral immune cell composition has not been examined in large human cohorts.
methodsWe estimated circulating proportions of 12 leukocyte subsets from the lymphoid and myeloid lineages by deconvolving cell-type-specific DNA methylation data from 4124 women. Hypertension status at baseline was defined by current use of antihypertensive medication and blood pressure measurements while new incident cases were identified during follow-up via annual health questionnaires.
resultsAmong hypertension-free women at baseline, higher B cell and lower naïve CD4+ helper T cell proportions were associated with subsequent increased hazard of hypertension incidence (B cells; adjusted HR: 1.17 [95% CI: 1.02-1.35];
conclusionsThese observations suggest that shifts in lymphocyte subsets occur before hypertension development, followed by later changes to neutrophils and additional lymphocytes.
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