ArticleHypertension (Dallas, Tex. : 1979)2022
Home Blood Pressure Can Predict the Risk for Stroke/Bleeding Events in Elderly Patients With Nonvalvular Atrial Fibrillation From the ANAFIE Registry.
Article in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 16 citations in OpenAlex.
- Home blood pressure-lowering effect of esaxerenone vs trichlormethiazide for uncontrolled hypertension: a prespecified subanalysis of the EXCITE-HT randomized controlled study by age subgroup.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Trial
- Age-stratified efficacy and safety of esaxerenone versus angiotensin II receptor blockers in older patients with hypertension: a predefined subanalysis of the ESCORT-HT study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- The impact of environmental pollution and climate change on hypertension: a position paper by the European Society of Hypertension (ESH) Working Group on Environment in Hypertension.Cardiovascular research · 2026Review
- Interrelationship Between the Morning-to-Evening Changes in Home Blood Pressure and Pulse Rate.American journal of hypertension · 2025Article
- Peak nocturnal home blood pressure as an early and strong novel risk factor for stroke: the practitioner-based nationwide J-HOP Nocturnal BP study.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Is atrial fibrillation a suitable target for studies on blood pressure variability?Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Coronary events in elderly patients with non-valvular atrial fibrillation: a prespecified sub-analysis of the ANAFIE registry.Cardiovascular intervention and therapeutics · 2024Observational
- The roles of electrocardiography and self-screening in the early detection of atrial fibrillation in hypertensive patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Anticoagulant therapy and home blood pressure-associated risk for stroke/bleeding events in elderly patients with non-valvular atrial fibrillation: the sub-cohort study of ANAFIE registry.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Home blood pressure-centered approach - from digital health to medical practice: HOPE Asia Network consensus statement 2023.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
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20 authors at 16 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundBlood pressure (BP) fluctuates significantly in patients with atrial fibrillation (AF); office BP measurements seem insufficient to assess AF patient risk accurately. We hypothesized that home BP could better predict the risk of stroke/systemic embolic events (SEE) and major bleeding in patients with AF than office BP.
methodsIn this prespecified subcohort study of the ANAFIE (All Nippon AF in the Elderly) Registry, we evaluated the impact of home BP on the risk of stroke/SEE, major bleeding, intracranial hemorrhage, all-cause death, and net cardiovascular outcome (a composite of stroke/SEE and major bleeding). At enrollment, home BP was measured twice in the morning and evening for 7 days.
resultsIn total, 4933 elderly patients (aged ≥75 years) with nonvalvular AF participated. Incidences of net cardiovascular outcome, stroke/SEE, major bleeding, and intracranial hemorrhage increased significantly with increasing home systolic BP (H-SBP). Compared with H-SBP <125 mm Hg, ≥145 mm Hg was associated with increased risk of these events. The association between H-SBP and the events was observed only in patients with ≥20 H-SBP measurements.
conclusionsIn elderly patients with nonvalvular AF, high H-SBP (≥145 mm Hg) was a significant predictor of stroke/SEE, major bleeding, and intracranial hemorrhage risk. Strict BP control guided by the increasing number of home BP measurements may provide an accurate clinical outcome risk assessment. REGISTRATION: URL: https://www.umin.ac.jp/ctr; Unique identifier: UMIN000024006.
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