Evidence map›Paper›PMID 36259376›Full record

ArticleHypertension (Dallas, Tex. : 1979)2022

Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (

McKenzie L Ritter, Guorui Deng, John J Reho, Yue Deng, Sarah A Sapouckey, Megan A Opichka, Kirthikaa Balapattabi, Kelsey K Wackman, Daniel T Brozoski, Ko-Ting Lu and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Angiotensin ATiScience · 2025
    Article
  3. Angiotensin ATCell reports · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

McKenzie L RitterDepartment of Physiology (M.L.R., J.J.R., M.A.O., K.B., K.K.W., D.T.B., K.-T.L., P.N., C.D.S., J.L.G.), Neuroscience Research Center, Medical College of Wisconsin, Milwaukee.
Guorui DengMedical College of Wisconsin, Milwaukee. Department of Pharmacology and Neuroscience (G.D., Y.D., S.A.S., H.C.), University of Iowa, Iowa City.ORCID 0000-0002-4629-7722
John J RehoDepartment of Physiology (M.L.R., J.J.R., M.A.O., K.B., K.K.W., D.T.B., K.-T.L., P.N., C.D.S., J.L.G.), Neuroscience Research Center, Medical College of Wisconsin, Milwaukee.
Yue DengMedical College of Wisconsin, Milwaukee. Department of Pharmacology and Neuroscience (G.D., Y.D., S.A.S., H.C.), University of Iowa, Iowa City.ORCID 0000-0001-8874-911X
Sarah A SapouckeyMedical College of Wisconsin, Milwaukee. Department of Pharmacology and Neuroscience (G.D., Y.D., S.A.S., H.C.), University of Iowa, Iowa City.
Megan A OpichkaDepartment of Physiology (M.L.R., J.J.R., M.A.O., K.B., K.K.W., D.T.B., K.-T.L., P.N., C.D.S., J.L.G.), Neuroscience Research Center, Medical College of Wisconsin, Milwaukee.ORCID 0000-0002-2961-8977
Kirthikaa BalapattabiDepartment of Physiology (M.L.R., J.J.R., M.A.O., K.B., K.K.W., D.T.B., K.-T.L., P.N., C.D.S., J.L.G.), Neuroscience Research Center, Medical College of Wisconsin, Milwaukee.ORCID 0000-0001-5455-6037
Kelsey K WackmanDepartment of Physiology (M.L.R., J.J.R., M.A.O., K.B., K.K.W., D.T.B., K.-T.L., P.N., C.D.S., J.L.G.), Neuroscience Research Center, Medical College of Wisconsin, Milwaukee.
Daniel T BrozoskiDepartment of Physiology (M.L.R., J.J.R., M.A.O., K.B., K.K.W., D.T.B., K.-T.L., P.N., C.D.S., J.L.G.), Neuroscience Research Center, Medical College of Wisconsin, Milwaukee.
Ko-Ting LuDepartment of Physiology (M.L.R., J.J.R., M.A.O., K.B., K.K.W., D.T.B., K.-T.L., P.N., C.D.S., J.L.G.), Neuroscience Research Center, Medical College of Wisconsin, Milwaukee.
William J ParadeeGenome Editing Core Facility (W.J.P.), University of Iowa, Iowa City.
Katherine N Gibson-CorleyDepartment of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN (K.N.G.-C.).ORCID 0000-0002-1846-1580
Huxing CuiMedical College of Wisconsin, Milwaukee. Department of Pharmacology and Neuroscience (G.D., Y.D., S.A.S., H.C.), University of Iowa, Iowa City.
Pablo NakagawaDepartment of Physiology (M.L.R., J.J.R., M.A.O., K.B., K.K.W., D.T.B., K.-T.L., P.N., C.D.S., J.L.G.), Neuroscience Research Center, Medical College of Wisconsin, Milwaukee.ORCID 0000-0002-1887-7367
Lisa L MorselliDepartment of Medicine, Division of Endocrinology (L.L.M.), Neuroscience Research Center, Medical College of Wisconsin, Milwaukee.
Curt D SigmundDepartment of Physiology (M.L.R., J.J.R., M.A.O., K.B., K.K.W., D.T.B., K.-T.L., P.N., C.D.S., J.L.G.), Neuroscience Research Center, Medical College of Wisconsin, Milwaukee.ORCID 0000-0002-1453-0921
Justin L GrobeDepartment of Physiology (M.L.R., J.J.R., M.A.O., K.B., K.K.W., D.T.B., K.-T.L., P.N., C.D.S., J.L.G.), Neuroscience Research Center, Medical College of Wisconsin, Milwaukee.ORCID 0000-0001-9737-0873
Medical College of Wisconsin · USUniversity of Iowa · USVanderbilt University · US

Funding

Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2007 to 2022
$30.2M
Multidisciplinary Lung Research Career Development ProgramT32HL007638 · NHLBI · UNIVERSITY OF IOWA · PI WELSH, MICHAEL J., ZABNER, JOSEPH · 1986 to 2020
$16.9M
PPARG-dependent Mechanisms Control Endothelial-Smooth Muscle Coordination, Arterial Pressure, Vasomotor Function and Arterial StiffnessR35HL144807 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI SIGMUND, CURT DANIEL · 2019 to 2024
$5.5M
Interaction between leptin and angiotensin in the pathogenesis of obesity-hypertensionR01HL134850 · NHLBI · UNIVERSITY OF IOWA · PI Justin L Grobe · 2017 to 2026
$4.4M
Decoding brain circuit underlying metabolic regulation of sleep-wake behaviorR01HL153274 · NHLBI · UNIVERSITY OF IOWA · PI CUI, HUXING · 2021 to 2024
$2.7M
Lateral Hypothalamic Regulation of Sympathetic Nerve Activity and Blood PressureR01HL127673 · NHLBI · UNIVERSITY OF IOWA · PI CUI, HUXING · 2016 to 2020
$2.0M
Impact of Early Life Sodium Intake on Growth and Metabolism – Role of Hypothalamic MechanismsR01DK133121 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI GROBE, JUSTIN L, SEGAR, JEFFREY L · 2022 to 2025
$1.9M
Role of the prorenin receptor in blood pressure and autonomic control through the local activation of the renin angiotensin system in the brainstemK01HL153101 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI NAKAGAWA, PABLO · 2020 to 2024
$562k
NCATS NIH HHS UL1 TR001436NHLBI NIH HHS K01 HL153101NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R01 HL127673NHLBI NIH HHS R01 HL134850NHLBI NIH HHS R01 HL153274NHLBI NIH HHS R35 HL144807NHLBI NIH HHS T32 HL007638NIDDK NIH HHS R01 DK133121
6 · The paper itself

Abstract

backgroundRGS (regulator of G protein signaling) family members catalyze the termination of G protein signaling cascades. Single nucleotide polymorphisms in the

methodsTo study cell-specific functions of RGS2, a novel gene-targeted mouse harboring a conditional allele for the

resultsWhereas

conclusionsThese results demonstrate the development of a novel mouse with conditional expression of

Indexed as

HypertensionRGS ProteinsAgouti-Related ProteinAnimalsMiceMice, KnockoutMice, TransgenicReceptor, Angiotensin, Type 1RecombinasesAgouti-Related ProteinReceptor, Angiotensin, Type 1RecombinasesRGS Proteinsanimal modelG protein coupled receptorGTPase-activating proteinsmousesecond-messenger

Identifiers

PMID36259376
PMCPMC9649888
OpenAlexW4306780628

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.