Evidence map›Paper›PMID 36259348›Full record

ArticleMolecular genetics & genomic medicine2022

Gene polymorphisms of cyclin-dependent kinase inhibitor and matrix metalloproteinase-9 in Sudanese patients with esophageal squamous cell carcinoma.

Majdolin Mohammed Eltayeb, Mohamed M Ali, Saeed M Omar, Nouh Saad Mohamed, Ishag Adam, Hamdan Z Hamdan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics & genomic medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Majdolin Mohammed EltayebFaculty of Medicine, Bahri University, Khartoum, Sudan.
Mohamed M AliFaculty of Medicine, Bahri University, Khartoum, Sudan.
Saeed M OmarFaculty of Medicine, Gadarif University, Gadarif, Sudan.
Nouh Saad MohamedMolecular Biology Unit, Sirius Training and Research Centre, Khartoum, Sudan.
Ishag AdamDepartment of Obstetrics and Gynecology, Unaizah College of Medicine, Qassim University, Unaizah, Kingdom of Saudi Arabia.
Hamdan Z HamdanDepartment of Basic Medical Sciences, Unaizah College of Medicine, Qassim University, Unaizah, Kingdom of Saudi Arabia.ORCID 0000-0001-9269-8239
Qassim University · SAUniversity of Bahri · SDGadarif University · SDNational Centre for Research · SD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe polymorphisms of the cyclin-dependent kinase inhibitor (CDKN1A) gene and matrix metalloproteinase-9 (MMP9) gene may increase one's susceptibility to malignancies. In this study, the association of the single nucleotide polymorphisms (SNPs) CDKN1A rs1059234 c.70C>T at the 3' untranslated region and MMP9 rs17576 (c.836A>G, p.Gln279Arg) with esophageal squamous cell carcinoma (ESCC) in Sudanese individuals were investigated. MATERIALS AND

methodsA case-control study involving age- and gender-matched groups were conducted in a cancer center in eastern Sudan (Gadarif) between April and October 2020. The case group consisted of ESCC patients, whereas the control group comprised healthy subjects. Polymerase chain reaction-restriction fragment length polymorphism was performed for the genotyping of the CDKN1A rs1059234 and MMP9 rs17576 SNPs. The genotyping results were confirmed by Sanger sequencing.

resultsThe genotype distributions for CDKN1A rs1059234 and MMP9 rs17576 were in agreement with the Hardy-Weinberg equilibrium. The variant allele T in CDKN1 rs1059234 c.70C>T was significantly more prevalent in the ESCC patients than in the healthy controls [51.3% vs. 19.2%; OR = 4.4; 95% CI (2.6-7.4); p < 0.001]. Moreover, in CDKN1A rs1059234, the genotype TC + TT [76.9% vs. 38.4%; OR = 5.3; 95% CI (2.6-10.7); p < 0.001] was more frequent in the cases than in the controls, and it was significantly associated with ESCC risk. In MMP9 rs17576, the variant allele G was also significantly prevalent in the cases relative to the controls, and it was significantly associated with increased ESCC risk in the cases compared with the controls [27.5% vs. 1.9%; OR = 19.4; 95%CI (5.8-64.1); p < 0.001]. Both genotypes containing the allele G (AG + GG) were the most common genotypes in the cases [48.7% vs. 3.8%; OR = 23.7; 95%CI (6.8-81.7); p < 0.001], and they significantly increased the risk of ESCC.

conclusionA significant increase in ESCC risk is associated with the SNPs CDKN1A rs1059234 and MMP9 rs17576.

Indexed as

Cyclin-Dependent Kinase Inhibitor p21Esophageal NeoplasmsEsophageal Squamous Cell CarcinomaMatrix Metalloproteinase 9Case-Control StudiesGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotideCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21Matrix Metalloproteinase 9MMP9 protein, humancyclin-dependent kinase inhibitor (CDKN1A)esophageal squamous cell carcinomamatrix metalloproteinase 9 (MMP9)single nucleotide polymorphismSudan

Identifiers

PMID36259348
PMCPMC9747550
OpenAlexW4306777405

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.