Evidence map›Paper›PMID 36258924›Full record

ArticleHemaSphere2022

Haploidentical Versus Matched Sibling Donor Hematopoietic Stem Cell Transplantation for Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia: A Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.

Arnon Nagler, Myriam Labopin, Ryszard Swoboda, Pietro Pioltelli, Mutlu Arat, Ibrahim Yakoub-Agha, Alexander Kulagin, Anna Maria Raiola, Hakan Ozdogu, Antonio Risitano and 7 more

Open access · goldAbstract read
In one paragraph

Article in HemaSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 14 institutions in 8 countries.

Arnon NaglerDivision of Hematology, Sheba Medical Center, Tel Hashomer, Israel.
Myriam LabopinALWP of the EBMT Paris Office, France.
Ryszard SwobodaDepartment of Bone Marrow Transplantation and Onco-Hematology, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.
Pietro PioltelliOspedale San Gerardo, Clinica Ematologica dell`Universita Milano-Biocca, Monza, Italy.
Mutlu AratHematopoietic SCT Unit, Demiroglu Bilim University Istanbul Florence Nightingale Hospital, Istanbul, Turkey.
Ibrahim Yakoub-AghaCHU de Lille LIRIC, INSERM U995, Université de Lille, Lille, France.
Alexander KulaginRM Gorbacheva Research Institute, Pavlov University, St Petersburg, Russia.
Anna Maria RaiolaEmatologia e Terapie Cellulari, IRCCS Ospedale Policlinico, San Martino, Genova, Italy.
Hakan OzdoguHaematology Division, BMT Unit, Baskent University Hospital, Hematology Research Laboratory, Training & Medical, Adana, Turkey.
Antonio RisitanoA.O.R.N. 'SAN.G MOSCATI', Ematologia, Avellino, Italy.
Zubeyde Nur OzkurtGazi University Faculty of Medicine, Hematology, Ankara, Turkey.
Jaime SanzHospital Universitari i Politècnic La Fe, Valencia, Spain.
Eolia BrissotService d'Hématologie Clinique et Thérapie Cellulaire, Hôpital Saint-Antoine, Sorbonne Université, INSERM UMRs 938, Paris, France.
Peric ZinaSchool of Medicine, University Hospital Centre Zagreb, University of Zagreb, Croatia.
Sebastian GiebelDepartment of Bone Marrow Transplantation and Onco-Hematology, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.
Fabio CiceriOspedale San Raffaele s.r.l. Hematology and BMT, Milano, Italy.
Mohamad MohtyDepartment of Hematology, Hospital Saint Antoine, EBMT Paris Study Office/CREST-TC, Saint Antoine Hospital, Paris, France.
Inserm · FRThe Maria Sklodowska-Curie National Research Institute of Oncology · PLAzienda Ospedaliera San Gerardo · ITAzienda Ospedaliera S.Giuseppe Moscati · ITBaşkent University · TRCentre de Recherche en Économie et Statistique · FRFirst Pavlov State Medical University of St. Petersburg · RUGazi University · TRHospital Universitari i Politècnic La Fe · ESIRCCS Ospedale San Raffaele · ITIstanbul Bilim University · TROspedale Policlinico San Martino · ITSheba Medical Center · ILUniversity Hospital Centre Zagreb · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The results of haploidentical stem cell transplantation (haploHCT) for patients with acute lymphoblastic leukemia (ALL) transplanted in active disease remain largely unknown. We retrospectively analyzed adult patients with R/R ALL who underwent haploHCT or matched sibling donor (MSD-HCT) as a first transplantation between 2012 and 2020. The analysis comprised 274 patients, 94 had a haploHCT, and 180 had an MSD-HCT. The median follow-up was 32 months. The median age was 33 (range 18-76) and 37 (18-76) years in the haplo- and MSD-HCT groups, respectively. Post-transplant cyclophosphamide (PTCy) was used in 88% of haploHCT and in 4% of the MSD-HCT group. Graft-versus-host disease grade III-IV was higher in haploHCT than in the MSD-HCT group (18% versus 9%;

Identifiers

PMID36258924
PMCPMC9575736
OpenAlexW4305013679

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.