Evidence map›Paper›PMID 36258805›Full record

ArticleCureus2022

COVID-19 Vaccination-Induced Cholangiopathy and Autoimmune Hepatitis: A Series of Two Cases.

Mansoor Zafar, Katherine Gordon, Lucia Macken, Joe Parvin, Simon Heath, Max Whibley, Jeremy Tibble

Abstract readCase Reports
In one paragraph

Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Post-COVID-19 cholangiopathy: Systematic review.World journal of methodology · 2023
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mansoor ZafarGastroenterology/General Internal Medicine, Royal Sussex County Hospital, University Hospitals Sussex National Health Service (NHS) Foundation Trust, Brighton, GBR.
Katherine GordonGastroenterology, Royal Sussex County Hospital, University Hospitals Sussex National Health Service (NHS) Foundation Trust, Brighton, GBR.
Lucia MackenGastroenterology, Royal Sussex County Hospital, University Hospitals Sussex National Health Service (NHS) Foundation Trust, Brighton, GBR.
Joe ParvinGastroenterology/General Internal Medicine, Royal Sussex County Hospital, University Hospitals Sussex National Health Service (NHS) Foundation Trust, Brighton, GBR.
Simon HeathCellular Pathology, Royal Sussex County Hospital, University Hospitals Sussex National Health Service (NHS) Foundation Trust, Brighton, GBR.
Max WhibleyCellular Pathology, Royal Sussex County Hospital, University Hospitals Sussex National Health Service (NHS) Foundation Trust, Brighton, GBR.
Jeremy TibbleGastroenterology/Hepatology, Royal Sussex County Hospital, University Hospitals Sussex National Health Service (NHS) Foundation Trust, Brighton, GBR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has been associated with significant morbidity and mortality. Following the introduction of vaccines, various side effects have been reported. Whilst those reported may be attributed to the vaccine itself, at times, it may simply incite an immunological phenomenon. We present a case series of two patients who presented with symptoms of yellowing of the eyes and the skin along with fatigue, and tiredness, following vaccination for COVID-19. The diagnosis of post COVID-19-vaccination related hepatitis is one of the fewer, less understood, yet reported side effects associated with significant morbidity. The diagnosis of COVID-19 vaccination-related cholangitis is an outcome reported here for the first time to the best of our knowledge. It was alarming that both patients did not have any significant past history of medical ailments. A prompt assessment followed by investigations including liver biopsy assisted in a timely understanding of the phenomenon with complete resolution of the symptoms.

Indexed as

alt (alanine aminotransferase)c –reactive protein (crp)emergency medical servicehematoxylin & eosinliver function tests (lfts)magnetic resonance cholangiopancreatography (mrcp)mrna

Identifiers

PMID36258805
PMCPMC9565316

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.