Evidence map›Paper›PMID 36258655›Full record

Trial reportDepression and anxiety2022

A pilot randomized effectiveness trial of the unified protocol in trauma-exposed veterans.

Cassidy A Gutner, Jiyoung Song, Caroline A Canale, Michael K Suvak, Scott D Litwack, Barbara L Niles, Shannon Wiltsey Stirman

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Depression and anxiety, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02944994 (Effectiveness of a Unified Transdiagnostic Treatment in Routine Clinical Care), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02944994 nacompletednot on this map

Effectiveness of a Unified Transdiagnostic Treatment in Routine Clinical Care

TypeinterventionalSponsorBoston UniversityRan2014 to 2019Enrolled71ConditionsAnxiety, Traumatic Stress Disorders, DepressionArmsUnified protocol, Routine Care
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Differentiating U.S. military women veterans with suicidal ideation, suicide attempts, and no suicidal ideation or attempts.Military psychology : the official journal of the Division of Military Psychology, American Psychological Association · 2026
    Article
  4. The effect of a reduction in irrational beliefs on Posttraumatic Stress Disorder (PTSD), depression, and anxiety symptoms in a group treatment for post-9/11 Veterans.Military psychology : the official journal of the Division of Military Psychology, American Psychological Association · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cassidy A GutnerDepartment of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-9406-6638
Jiyoung SongDepartment of Psychology, University of California, Berkeley, Berkeley, California, USA.
Caroline A CanaleDepartment of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA.
Michael K SuvakDepartment of Psychology, Suffolk University, Boston, Massachusetts, USA.
Scott D LitwackDepartment of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA.
Barbara L NilesDepartment of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA.
Shannon Wiltsey StirmanDissemination and Education Division of the National Center for PTSD, Menlo Park, California, United States.

Funding

Effectiveness of a unified transdiagnostic treatment in routine clinical careK23MH103396 · NIMH · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GUTNER, CASSIDY AUBIN · 2015 to 2019
$898k
NIMH NIH HHS K23 MH103396
6 · The paper itself

Abstract

backgroundThe unified protocol (UP) is a promising transdisgnostic treatment for emotional disorders; limited data exists with trauma-exposed populations. This study compared effectiveness of the UP, presented centered therapy (PCT), and treatment as usual (TAU) in trauma-exposed veterans presenting to routine care.

methodTrauma-exposed veterans with one or more emotional disorder diagnoses participated in a pilot hybrid-1 effectiveness/preimplementation study. Thirty-seven male and female veterans were randomized to one of three conditions.

resultsMultilevel growth curve modeling demonstrated improvement over time across conditions with large effect sizes (range: -2.15 to -3.32), with the UP demonstrating the greatest change. The between group effect sizes for reductions in number of comorbid diagnoses were medium to small and statistically significant (TAU and UP, d = 0.49, p = .056; TAU and PCT d = 0.18, p = .166, UP and PCT d = 0.31, p = .229). Only the UP led to a decrease in the number of comorbid diagnoses (d = -0.71). Psychosocial functioning varied by group, with slight increases in impairment in PCT and TAU, and medium effect size reduction in the UP. Only the UP exhibited significant decreases in self-reported anxiety and depression. Between group differences for UP and PCT were medium to large and statistically significant for depression across two measures (d = -0.72 to d = -1.40).

conclusionsThis represents the first trial examining effectiveness of the UP, PCT, and TAU in trauma-exposed veterans. Despite a small sample, large effect size differences demonstrated promising advantages for the UP. Trial Registration Number: NCT02944994.

Indexed as

Stress Disorders, Post-TraumaticVeteransAnxietyComorbidityFemaleHumansMalePilot ProjectsTreatment OutcomeanxietycomorbiditydepressionPTSDtransdiagnostictraumaveteran

Identifiers

PMID36258655
PMCPMC9729399

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.