Evidence map›Paper›PMID 36258653›Full record

ArticleHIV medicine2022

Estimation of the determinants for HIV late presentation using the traditional definition and molecular clock-inferred dates: Evidence that older age, heterosexual risk group and more recent diagnosis are prognostic factors.

Evangelia Georgia Kostaki, Stefanos Limnaios, Georgios Adamis, Georgios Xylomenos, Maria Chini, Nikos Mangafas, Marios Lazanas, Stavros Patrinos, Simeon Metallidis, Olga Tsachouridou and 28 more

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Article in HIV medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Missed opportunities for early HIV diagnosis in Greece: The MORFEAS study, 2019 to 2021.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Evangelia Georgia KostakiDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0002-3346-0930
Stefanos LimnaiosDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Georgios Adamis1st Department of Internal Medicine, G. Gennimatas General Hospital, Athens, Greece.
Georgios Xylomenos1st Department of Internal Medicine, G. Gennimatas General Hospital, Athens, Greece.
Maria Chini3rd Department of Internal Medicine-Infectious Diseases Unit, "Korgialeneio-Benakeio" Red Cross General Hospital, Athens, Greece.
Nikos Mangafas3rd Department of Internal Medicine-Infectious Diseases Unit, "Korgialeneio-Benakeio" Red Cross General Hospital, Athens, Greece.
Marios Lazanas3rd Department of Internal Medicine-Infectious Diseases Unit, "Korgialeneio-Benakeio" Red Cross General Hospital, Athens, Greece.
Stavros PatrinosNational Public Health Organization, Athens, Greece.
Simeon Metallidis1st Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Olga Tsachouridou1st Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Vasileios Papastamopoulos5th Department of Internal Medicine and Infectious Diseases, Evaggelismos General Hospital, Athens, Greece.
Dimitrios ChatzidimitriouNational AIDS Reference Centre of Northern Greece, Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Anastasia Antoniadou4th Department of Medicine, Attikon General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Antonios Papadopoulos4th Department of Medicine, Attikon General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Konstantinos Protopapas4th Department of Medicine, Attikon General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Chrysa TsiaraNational Public Health Organization, Athens, Greece.
Mina Psichogiou1st Department of Medicine, Laikon General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Dimitrios Basoulis1st Department of Medicine, Laikon General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Dimitrios PilalasNational AIDS Reference Centre of Northern Greece, Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Dimitra ParaskevaDepartment of Internal Medicine, Tzaneio General Hospital, Piraeus, Greece.
Georgios ChrysosDepartment of Internal Medicine, Tzaneio General Hospital, Piraeus, Greece.
Vasileios PaparizosHIV/AIDS Unit, A. Syngros Hospital of Dermatology and Venereology, Athens, Greece.
Sofia KourkountiHIV/AIDS Unit, A. Syngros Hospital of Dermatology and Venereology, Athens, Greece.
Helen SambatakouHIV Unit, 2nd Department of Internal Medicine, Hippokration General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Vasileios BolanosHIV Unit, 2nd Department of Internal Medicine, Hippokration General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Nikolaos V SipsasDepartment of Pathophysiology, Laikon General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Malvina Lada2nd Department of Internal Medicine, Sismanogleion General Hospital, Athens, Greece.
Emmanouil BarbounakisDepartment of Internal Medicine, University Hospital of Heraklion "PAGNI", Medical School, University of Crete, Heraklion, Greece.
Evrikleia KantzilakiDepartment of Internal Medicine, University Hospital of Heraklion "PAGNI", Medical School, University of Crete, Heraklion, Greece.
Periklis PanagopoulosDepartment of Internal Medicine, University General Hospital, Democritus University of Thrace, Alexandroupolis, Greece.
Vasilis PetrakisDepartment of Internal Medicine, University General Hospital, Democritus University of Thrace, Alexandroupolis, Greece.
Stelios DrimisDepartment of Internal Medicine, Tzaneio General Hospital, Piraeus, Greece.
Ioannis KatsarolisMedical Affairs, Gilead Sciences Hellas, Athens, Greece.
Pagona LagiouDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Angelos HatzakisDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Gkikas MagiorkinisDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Lemonia SkouraNational AIDS Reference Centre of Northern Greece, Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Dimitrios ParaskevisDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0001-6167-7152

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesHIV late presentation (LP) has been increasing in recent years in Europe. Our aim was to investigate the characteristics of LP in Greece using in addition to the traditional definition for LP, the time interval between HIV infection and diagnosis.

methodsOur nationwide sample included HIV-1 sequences generated from 6166 people living with HIV (PLWH) in Greece during the period 1999-2015. Our analysis was based on the molecularly inferred HIV-1 infection dates for PLWH infected within local molecular transmission clusters of subtypes A1 and B.

resultsAnalysis of the determinants of LP was conducted using either CD4 counts or AIDS-defining condition at diagnosis or the time from infection to diagnosis. Older age, heterosexual transmission risk group and more recent diagnosis were associated with increased risk for LP. In contrast to previous studies, people who inject drugs (PWID) had a shorter median time to diagnosis (0.63 years) compared to men who have sex with men (MSM) (1.72 years) and heterosexuals (2.43 years). Using HIV infection dates that provide an unbiased marker for LP compared to CD4 counts at diagnosis, which are age-dependent, we estimated that the time to diagnosis increased gradually with age. Migrants infected regionally do not differ with respect to LP status compared to native Greeks.

conclusionsWe demonstrate that older people and heterosexuals are among those at higher risk for LP; and given the growing number of older people among newly diagnosed cases, tailored interventions are needed in these populations.

Indexed as

Acquired Immunodeficiency SyndromeHIV InfectionsSexual and Gender MinoritiesAgedCD4 Lymphocyte CountDelayed DiagnosisHeterosexualityHomosexuality, MaleHumansMalePrognosisRisk FactorsGreeceHIVinfection dateslate presentationmolecular epidemiologyrisk factors

Identifiers

PMID36258653
PMCPMC10092532

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