Evidence map›Paper›PMID 36258228›Full record

ArticleCell & bioscience2022

Long-term maintenance of human endometrial epithelial stem cells and their therapeutic effects on intrauterine adhesion.

Wen He, Xuejing Zhu, Aijie Xin, Hongdan Zhang, Yiming Sun, Hua Xu, He Li, Tianying Yang, Dan Zhou, Hexin Yan and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Application of adult stem cells in obstetrics and gynecology: A scoping review.European journal of obstetrics & gynecology and reproductive biology: X · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Wen He *Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Xuejing Zhu *Shanghai Celliver Biotechnology Co. Ltd, Shanghai, China.
Aijie Xin *NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Fudan University, Shanghai, China.
Hongdan ZhangShanghai Celliver Biotechnology Co. Ltd, Shanghai, China.
Yiming SunObstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Hua XuShanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
He LiShanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Tianying YangObstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Dan ZhouObstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Hexin YanShanghai Celliver Biotechnology Co. Ltd, Shanghai, China. hexin.yan@celliver.com.
Xiaoxi SunObstetrics and Gynecology Hospital, Fudan University, Shanghai, China. xiaoxi_sun@aliyun.com.ORCID http://orcid.org/0000-0002-3366-5821
Obstetrics and Gynecology Hospital of Fudan University · CNFudan University · CNShanghai Cell Therapy Research Institute · CNShangHai JiAi Genetics & IVF Institute · CN

Funding

Shanghai Scientific and Technological Innovation Program 19441910900
6 · The paper itself

Abstract

backgroundThe human endometrium is a highly regenerative tissue that is believed to have two main types of stem cells: endometrial mesenchymal/stromal stem cells (eMSCs) and endometrial epithelial stem cells (eESCs). So far, eMSCs have been extensively studied, whereas the studies of eESCs are constrained by the inability to culture and expand them in vitro. The aim of this study is to establish an efficient method for the production of eESCs from human endometrium for potential clinical application in intrauterine adhesion (IUA).

resultsHere we developed a culture condition with a combination of some small molecules for in vitro culturing and expansion of human SSEA-1

conclusionsOur work demonstrates an approach for isolation and expansion of human eESCs in vitro, and an appropriate marker, SSEA-1, to identify eESCs. Furthermore, the SSEA-1

Indexed as

Endometrial regenerationEndometrial stem cellIntrauterine adhesionSSEA-1

Identifiers

PMID36258228
PMCPMC9580151
OpenAlexW4306725820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.