Evidence map›Paper›PMID 36258207›Full record

ArticleBMC endocrine disorders2022

Superoxide-producing thermostable associate from the small intestines of control and alloxan-induced diabetic rats: quantitative and qualitative changes.

R M Simonyan, K V Simonyan, G M Simonyan, H S Khachatryan, M A Babayan, M H Danielyan, L V Darbinyan, M A Simonyan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC endocrine disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

R M SimonyanH. Buniatyan Institute of Biochemistry NAS RA, 0014, Yerevan, Armenia.
K V SimonyanNeuroendocrine Relationships Lab, Orbeli Institute of Physiology NAS RA, 0028, Yerevan, Armenia. karensimonyan86@gmail.com.
G M SimonyanH. Buniatyan Institute of Biochemistry NAS RA, 0014, Yerevan, Armenia.
H S KhachatryanH. Buniatyan Institute of Biochemistry NAS RA, 0014, Yerevan, Armenia.
M A BabayanH. Buniatyan Institute of Biochemistry NAS RA, 0014, Yerevan, Armenia.
M H DanielyanHistochemistry and Electron microscopy Lab, Orbeli Institute of Physiology NAS RA, 0028, Yerevan, Armenia.
L V DarbinyanSensorimotor Integration Lab, Orbeli Institute of Physiology NAS RA, 0028, Yerevan, Armenia.
M A SimonyanH. Buniatyan Institute of Biochemistry NAS RA, 0014, Yerevan, Armenia.
L. A. Orbeli Institute of Physiology NAS RA · AMNational Academy of Sciences of Armenia · AMH.Buniatian Institute of Biochemistry · AM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNADPH oxidase 1 (Nox1), which is highly expressed in the colon, is thought to play a potential role in host defense as a physical and innate immune barrier against commensal or pathogenic microbes in the gastrointestinal epithelium. Diabetes can be caused by several biological factors, including insulin resistance is one of them. Alloxan is widely used to induce insulin-dependent diabetes in experimental animals. Alloxan increases the generation of reactive oxygen species as a result of metabolic reactions in the body, along with a massive increase in cytosolic calcium concentration.

methodsUsing a universal method, a superoxide radical (О

resultsIn comparison to the C indices, in AD in the SI, an increase in the specific content of NLP-Nox associate and a decrease in the stationary concentration of produced О

conclusionThus, at AD, the decrease in the stationary concentration of produced О

Indexed as

Diabetes Mellitus, ExperimentalInsulinsAlloxanAnimalsCalciumDithioniteIntestine, SmallLipoproteinsNADPNADPH Oxidase 1NADPH OxidasesOxygenPotassiumRatsReactive Oxygen SpeciesSuperoxidesAlloxanCalciumDithioniteInsulinsLipoproteinsNADPNADPH Oxidase 1NADPH OxidasesOxygenPotassiumReactive Oxygen SpeciesSuperoxidesAlloxan diabetesAssociateSmall intestineSuperoxide

Identifiers

PMID36258207
PMCPMC9580182
OpenAlexW4306748485

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.