ReviewNature human behaviour2022
Social isolation and the brain in the pandemic era.
Review in Nature human behaviour, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed.
- Effects of home-based exercise with or without cognitive training on cognition and mobility in cardiac patients: A randomized clinical trial.GeroScience · 2025Trial
- Emotional reactivity and decision-making under social deprivation: the role of trait anxiety during quarantine.Royal Society open science · 2026Article
- Global burden of mental disorders among women of child-bearing age, 1990-2021, with projections to 2050.European archives of psychiatry and clinical neuroscience · 2026Article
- PTSD symptoms, loneliness, and amygdala volumes during pandemic social distancing associated with risk of suicidal ideation in trauma survivors with and without pre-pandemic PTSD.Journal of affective disorders reports · 2026Article
- Sense of control buffers against stress.eLife · 2026Article
- Multimodal social context modulates larval behavior inScience advances · 2026Article
- Intrinsic network static and dynamic functional connectivity associated with induced affect.Social cognitive and affective neuroscience · 2026Article
- Understanding crisis dynamics during public health emergencies: an integrated framework of social consequences, trust, and behavioral responses.Frontiers in public health · 2026Review
- Digital connection: effect of online social capital and associated factors on adolescents' oral health-related quality of life.Brazilian oral research · 2026Article
- Neural circuit basis of pathological anxiety.Nature reviews. Neuroscience · 2025Review
- Impact of COVID-19 School Closures on White Matter Plasticity in the Reading Network.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Changes in social environment impact primate gut microbiota composition.Animal microbiome · 2024Article
- Sexual behaviours and risk of SARS-CoV-2 infection among MSM during the first COVID-19 lockdown.BMC public health · 2024Article
- COVID-19 and mental health consequences: moving forward.The lancet. Psychiatry · 2024Article
- Article
- (R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice.Molecular psychiatry · 2024Article
- Social isolation and the risk of Parkinson disease in the UK biobank study.NPJ Parkinson's disease · 2024Article
- Social Isolation, Brain Food Cue Processing, Eating Behaviors, and Mental Health Symptoms.JAMA network open · 2024Article
- Strength and resilience of developing brain circuits predict adolescent emotional and stress responses during the COVID-19 pandemic.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Psychometric Evaluation of the Autism Spectrum Rating Scales (6-18 Years Parent Report) in a Clinical Sample.Journal of autism and developmental disorders · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Intense sociality has been a catalyst for human culture and civilization, and our social relationships at a personal level play a pivotal role in our health and well-being. These relationships are, however, sensitive to the time we invest in them. To understand how and why this should be, we first outline the evolutionary background in primate sociality from which our human social world has emerged. We then review defining features of that human sociality, putting forward a framework within which one can understand the consequences of mass social isolation during the COVID-19 pandemic, including mental health deterioration, stress, sleep disturbance and substance misuse. We outline recent research on the neural basis of prolonged social isolation, highlighting especially higher-order neural circuits such as the default mode network. Our survey of studies covers the negative effects of prolonged social deprivation and the multifaceted drivers of day-to-day pandemic experiences.
Indexed as
Identifiers
36258130What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.