Evidence map›Paper›PMID 36258105›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023

Cognitive impairment in asymptomatic cerebral arterial stenosis: a P300 study.

Nevine El Nahas, Amr Zaki, Magd Zakaria, Azza Abd El Naser, Ahmed El Bassiony, Eman Abdeldayem, Hossam Shokri, Ahmed El Bokl

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Nevine El NahasNeurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Amr ZakiNeurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Magd ZakariaNeurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Azza Abd El NaserNeurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ahmed El BassionyNeurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Eman AbdeldayemNeurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Hossam ShokriNeurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. hossam.shokri@med.asu.edu.eg.ORCID http://orcid.org/0000-0001-6154-6806
Ahmed El BoklNeurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCerebral arterial stenosis (CAS), in the absence of a structural lesion, can result in cognitive impairment that represents an ongoing contention among studies. Accordingly, we investigated cognitive functions in asymptomatic patients with CAS, using P300 which is a neurophysiological tool. We also compared cognition in intracranial stenosis (ICS) and extracranial stenosis (ECS).

methodsAsymptomatic patients with CAS (≥ 70%) in the absence of structural brain lesions were categorized into ICS and ECS groups of 15 patients each, in addition to 15 normal controls. MRI, MRA, CT angiography, P300 analysis, Mini-Mental State examination (MMSE), Wisconsin Card Sorting Test (WCST), and Wechsler Memory Scale Test-Revised (WMST) were performed to all patients.

resultsImpairment on all cognitive scales ranged from 70 up to 100% among CAS group. Prolonged p300 latency and reaction time correlated with worse performance on WMST (p = 0.02), while lower amplitude and decreased accuracy correlated with more errors on WCST (p = 0.01). ICS scores on WCTS were lower than those of ECS group (p = 0.001), while ECS had a longer reaction time (p = 0.02) and lower scores on MMS and WMST than those of ICS group (p = 0.03).

conclusionPatients with asymptomatic CAS had a high prevalence of cognitive dysfunction which places them at risk of higher morbidity. ICS group showed impairment on executive functions, while the ECS group showed predilection to memory and information processing dysfunction.

Indexed as

Carotid StenosisCognitive DysfunctionCognitionConstriction, PathologicExecutive FunctionHumansNeuropsychological TestsAsymptomatic cerebral arterial stenosisCerebral arterial stenosisCognitive dysfunctionIntracranial stenosisStructural brain lesions

Identifiers

PMID36258105
PMCPMC9842544

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