Evidence map›Paper›PMID 36258070›Full record

ArticleAdvances in experimental medicine and biology2022

Pseudomonas aeruginosa Quorum Sensing.

Samantha Wellington Miranda, Kyle L Asfahl, Ajai A Dandekar, E P Greenberg

Abstract read
In one paragraph

Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Identification ofMicroorganisms · 2026
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  4. Review
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  6. Review
  7. Review
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  9. New inhibitors of themSphere · 2026
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  10. Inactivation of MexT inJournal of bacteriology · 2026
    Article
  11. Article
  12. Review
  13. Review
  14. Mechanisms of thermoregulation inJournal of bacteriology · 2026
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samantha Wellington Miranda *Department of Microbiology, University of Washington School of Medicine, Seattle, WA, USA.
Kyle L Asfahl *Department of Microbiology, University of Washington School of Medicine, Seattle, WA, USA.
Ajai A DandekarDepartment of Microbiology, University of Washington School of Medicine, Seattle, WA, USA.
E P GreenbergDepartment of Microbiology, University of Washington School of Medicine, Seattle, WA, USA. epgreen@uw.edu.

Funding

RESPIRATORY RESEARCH TRAINING PROGRAMT32HL007287 · NHLBI · UNIVERSITY OF WASHINGTON · PI Kristina Anne Crothers, David J. Horne · 1985 to 2026
$16.7M
Quorum sensing in Pseudomonas aeruginosa - Equipment SupplementR35GM136218 · NIGMS · UNIVERSITY OF WASHINGTON · PI Everett P Greenberg · 2020 to 2026
$2.9M
Pseudomonas aeruginosa quorum sensingR01GM125714 · NIGMS · UNIVERSITY OF WASHINGTON · PI DANDEKAR, AJAI · 2018 to 2022
$1.6M
NHLBI NIH HHS T32 HL007287NIGMS NIH HHS R01 GM125714NIGMS NIH HHS R35 GM136218Wellcome Trust
6 · The paper itself

Abstract

Pseudomonas aeruginosa, like many bacteria, uses chemical signals to communicate between cells in a process called quorum sensing (QS). QS allows groups of bacteria to sense population density and, in response to changing cell densities, to coordinate behaviors. The P. aeruginosa QS system consists of two complete circuits that involve acyl-homoserine lactone signals and a third system that uses quinolone signals. Together, these three QS circuits regulate the expression of hundreds of genes, many of which code for virulence factors. P. aeruginosa has become a model for studying the molecular biology of QS and the ecology and evolution of group behaviors in bacteria. In this chapter, we recount the history of discovery of QS systems in P. aeruginosa, discuss how QS relates to virulence and the ecology of this bacterium, and explore strategies to inhibit QS. Finally, we discuss future directions for research in P. aeruginosa QS.

Indexed as

QuinolonesQuorum SensingAcyl-ButyrolactonesBacterial ProteinsGene Expression Regulation, BacterialPseudomonas aeruginosaTrans-ActivatorsVirulence FactorsAcyl-ButyrolactonesBacterial ProteinsQuinolonesTrans-ActivatorsVirulence FactorsAcyl-homoserine lactoneCooperationLasRPqsRQuinoloneQuorum inhibitionRhlRSociomicrobiology

Identifiers

PMID36258070
PMCPMC9942581

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.