Evidence map›Paper›PMID 36258069›Full record

ReviewAdvances in experimental medicine and biology2022

Controlling Biofilm Development Through Cyclic di-GMP Signaling.

Soyoung Park, Karin Sauer

Abstract readReview
In one paragraph

Review in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Biofilm dispersion byJournal of bacteriology · 2026
    Article
  5. Calcium regulation ofApplied and environmental microbiology · 2026
    Article
  6. bioRxiv : the preprint server for biology · 2026
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Discovery of Novel c-di-GMP-Related Genes inPathogens (Basel, Switzerland) · 2026
    Article
  12. Review
  13. Article
  14. UnderstandingMicroorganisms · 2026
    Review
  15. Transcriptional profiling ofFrontiers in microbiology · 2026
    Article
  16. BioMed research international · 2026
    Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Soyoung ParkDepartment of Biological Sciences, Binghamton University, Binghamton, NY, USA.
Karin SauerDepartment of Biological Sciences, Binghamton University, Binghamton, NY, USA. ksauer@binghamton.edu.

Funding

Role of PA4878 in biofilm antimicrobial resistanceR01AI080710 · NIAID · STATE UNIVERSITY OF NY,BINGHAMTON · PI LAU, GEE W, SAUER, KARIN · 2009 to 2020
$3.1M
Dispersion and the Biofilm Matrix of Pseudomonas aeruginosaR01AI150761 · NIAID · STATE UNIVERSITY OF NY,BINGHAMTON · PI MATTHEW R. PARSEK, Karin Sauer · 2021 to 2026
$2.8M
NIAID NIH HHS R01 AI080710NIAID NIH HHS R01 AI150761
6 · The paper itself

Abstract

The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that regulates many bacterial behaviors and is of key importance for driving the lifestyle switch between motile loner cells and biofilm formers. This review provides an up-to-date summary of c-di-GMP pathways connected to biofilm formation by the opportunistic pathogen P. aeruginosa. Emphasis will be on the timing of c-di-GMP production over the course of biofilm formation, to highlight non-uniform and hierarchical increases in c-di-GMP levels, as well as biofilm growth conditions that do not conform with our current model of c-di-GMP.

Indexed as

Bacterial ProteinsGene Expression Regulation, BacterialBiofilmsCyclic GMPPseudomonas aeruginosaSecond Messenger SystemsSignal TransductionBacterial ProteinsCyclic GMPBiofilmCyclic di-GMPDiguanilate cyclaseNosocomial infectionPhosphodiesteraseSecond messenger

Identifiers

PMID36258069
PMCPMC9891824

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.