Evidence map›Paper›PMID 36258061›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2022

Do Lymph Node Metastases Matter in Appendiceal Cancer with Peritoneal Carcinomatosis? A US HIPEC Collaborative Study.

Kevin M Turner, Mackenzie C Morris, Aaron M Delman, Dennis Hanseman, Fabian M Johnston, Jonathan Greer, Kara Vande Walle, Daniel E Abbott, Mustafa Raoof, Travis E Grotz and 14 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Guideline
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 13 institutions in 1 country.

Kevin M TurnerDepartment of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0002-1962-5065
Mackenzie C MorrisDepartment of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Aaron M DelmanDepartment of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Dennis HansemanDepartment of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Fabian M JohnstonDepartment of Surgery, Johns Hopkins University, Baltimore, MD, USA.
Jonathan GreerDepartment of Surgery, Johns Hopkins University, Baltimore, MD, USA.
Kara Vande WalleDepartment of Surgery, Division of Surgical Oncology, University of Wisconsin, Madison, WI, USA.
Daniel E AbbottDepartment of Surgery, Division of Surgical Oncology, University of Wisconsin, Madison, WI, USA.
Mustafa RaoofDepartment of Surgery, Division of Surgical Oncology, City of Hope National Medical Center, Duarte, CA, USA.
Travis E GrotzDivision of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, MN, USA.
Keith FournierDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sean DineenDepartment of Gastrointestinal Oncology, Moffitt Cancer Center, Morsani College of Medicine, Tampa, FL, USA.
Jula VeerapongDepartment of Surgery, Division of Surgical Oncology, University of California, San Diego, San Diego, CA, USA.
Ugwuji MaduekweDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Anai KothariDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Charles A StaleyDivision of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Shishir K MaithelDivision of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Laura A LambertPeritoneal Surface Malignancy Program Section of Surgical Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Alex C KimDepartment of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Jordan M CloydDepartment of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Gregory C WilsonDepartment of Surgery, Division of Surgical Oncology, University of Cincinnati College of Medicine, Medical Science Building, 231 Albert Sabin Way, Cincinnati, OH, 45267-0558, USA.
Jeffrey J SussmanDepartment of Surgery, Division of Surgical Oncology, University of Cincinnati College of Medicine, Medical Science Building, 231 Albert Sabin Way, Cincinnati, OH, 45267-0558, USA.
Syed A AhmadDepartment of Surgery, Division of Surgical Oncology, University of Cincinnati College of Medicine, Medical Science Building, 231 Albert Sabin Way, Cincinnati, OH, 45267-0558, USA.
Sameer H PatelDepartment of Surgery, Division of Surgical Oncology, University of Cincinnati College of Medicine, Medical Science Building, 231 Albert Sabin Way, Cincinnati, OH, 45267-0558, USA. patel5se@ucmail.uc.edu.
Sabin Vaccine Institute · USUniversity of Cincinnati Medical Center · USEmory University · USJohns Hopkins University · USMedical College of Wisconsin · USThe Ohio State University Wexner Medical Center · USUniversity of Wisconsin–Madison · USCity Of Hope National Medical Center · USMayo Clinic in Arizona · USMoffitt Cancer Center · USThe University of Texas MD Anderson Cancer Center · USUniversity of California San Diego · USUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhether formal regional lymph node (LN) evaluation is necessary for patients with appendiceal adenocarcinoma (AA) who have peritoneal metastases is unclear. The aim of this study was to evaluate the prognostic value of LN metastases on survival in patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC).

methodsA retrospective analysis of the US HIPEC collaborative, a multi-institutional consortium comprising 12 high-volume centers, was performed to identify patients with AA who underwent CRS-HIPEC with adequate LN sampling (≥ 12 LNs).

resultsTwo hundred-fifty patients with AA who underwent CRS-HIPEC were included. Outcomes were compared between LN - and LN + disease. Baseline patient characteristics between groups were similar, with most patients undergoing complete cytoreduction (0/1: 86.0% vs. 76.8%, p = 0.08), respectively. More adverse tumor factors were found in patients with LN + disease, including poor differentiation, signet ring cells, and lymphovascular invasion. Multivariate analysis of overall survival (OS) found LN + disease was independently associated with worse OS (HR: 2.82 95%CI: 1.25-6.34, p = 0.01), even after correction for receipt of systemic therapy. On Kaplan-Meier analysis, median OS was lower in patients with LN + disease (25.9 months vs. 91.4 months, p < 0.01). LN + disease remained associated with poor OS following propensity score matching (HR: 4.98 95%CI: 1.72-14.40, p < 0.01) and in patients with PCI ≥ 20 (HR: 3.68 95%CI: 1.54-8.80, p < 0.01).

conclusionsIn this large multi-institutional study of patients with AA undergoing CRS-HIPEC, LN status remained associated with worse OS even in the setting of advanced peritoneal carcinomatosis. Formal LN evaluation should be performed for most patients with AA undergoing CRS-HIPEC.

Indexed as

AdenocarcinomaAdenocarcinoma, MucinousAppendiceal NeoplasmsHyperthermia, InducedPercutaneous Coronary InterventionPeritoneal NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, Cancer, Regional PerfusionCombined Modality TherapyCytoreduction Surgical ProceduresFollow-Up StudiesHumansHyperthermic Intraperitoneal ChemotherapyLymphatic MetastasisPrognosisRetrospective StudiesAppendiceal adenocarcinomaCytoreductive surgeryHIPECLymph node metastases

Identifiers

PMID36258061
OpenAlexW4306717566

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.