ArticleScientific reports2022
Antifungal activity and genomic characterization of the biocontrol agent Bacillus velezensis CMRP 4489.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- A Broad-Spectrum Antagonistic Bacillus Velezensis Strain HY17 as a Potential Biocontrol Agent Aagainst Major Maize Fungal Diseases.Current microbiology · 2026Article
- Biocontrol effect of a solid-state fermentation-derived extract mixture ofMicrobiology spectrum · 2026Article
- Genomic and Functional Characterization of Bacillus amyloliquefaciens H6: A Potent Fengycin-Producing Biocontrol Agent Against Fusarium graminearum.Probiotics and antimicrobial proteins · 2026Article
- Integrated chemical and genomic analysis of lipopeptides produced by Bacillus velezensis CMRP4489 with antifungal activity.Scientific reports · 2026Article
- Integrated genomic and phenotypic analysis of an endophytic bacterium reveals biocontrol and plant growth-promoting mechanisms.iScience · 2026Article
- Complete genome sequence ofMicrobiology resource announcements · 2026Article
- Magnetotactic bacteria as biostimulants for enhancing the growth and yield of tomato and paddy under abiotic stress.Frontiers in microbiology · 2026Article
- Next-generation antifungal peptide discovery: the synergy of artificial intelligence and omics technologies.World journal of microbiology & biotechnology · 2025Review
- Antimicrobial Potential of Secalonic Acids from Arctic-DerivedAntibiotics (Basel, Switzerland) · 2025Article
- New Ground in Antifungal Discovery and Therapy for Invasive Fungal Infections: Innovations, Challenges, and Future Directions.Journal of fungi (Basel, Switzerland) · 2024Review
- Genomic Insights into the Bactericidal and Fungicidal Potential ofMicroorganisms · 2024Article
- Enhanced Antifungal Efficacy of Validamycin A Co-Administered withPlants (Basel, Switzerland) · 2024Article
- Biocontrol in built environments to reduce pathogen exposure and infection risk.The ISME journal · 2024Review
- The role ofFrontiers in microbiology · 2024Review
- Whole genome analysis, detoxification of ochratoxin a and physiological characterization of a novelFrontiers in microbiology · 2024Article
- Adding Metal Ions to theJournal of fungi (Basel, Switzerland) · 2023Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of bio-based products has increased in recent years, and species of the Bacillus genus have been widely used for product development due to their elevated production of antimicrobial molecules and resistance to extreme environmental conditions through endospore formation. In this context, the antifungal potential of Bacillus velezensis CMRP 4489 was investigated using in silico predictions of secondary metabolites in its genome and in vitro tests against the following phytopathogenic fungi: Sclerotinia sclerotiorum, Macrophomina phaseolina, and Botrytis cinerea. The in-silico predictions indicated that CMRP 4489 possesses several Biosynthetic Gene Clusters (BGCs) capable of producing molecules with antifungal properties and other non-identified BGCs. The in vitro assay results evidenced strong antifungal activity, inhibiting more than 60% of the tested fungi, and the isolate's molecules were stable under diverse physicochemical conditions. The in vitro assay evidenced significant antifungal activity, deformation of the hyphal structure in SS, biofilm formation capacity, and swarming motility. In the colonization assay, we observed attachment, colonization, and net-shaped biofilm formation, with the strain transitioning from the seeds to nearby structures. Therefore, CMRP 4489 showed to be a potential biocontrol agent against various diseases with agronomic importance and can be used under adverse environmental conditions.
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