Evidence map›Paper›PMID 36257845›Full record

ReviewTrends in neurosciences2022

Emerging approaches for decoding neuropeptide transmission.

Kasey S Girven, Leandra Mangieri, Michael R Bruchas

Open access · greenAbstract readReview
In one paragraph

Review in Trends in neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  7. Pain persists in mice lacking both Substance P and CGRPα signaling.bioRxiv : the preprint server for biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kasey S GirvenDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA; University of Washington Center for the Neurobiology of Addiction, Pain, and Emotion, Seattle, WA, USA; Department of Pharmacology, University of Washington, Seattle, WA, USA.
Leandra MangieriDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA; University of Washington Center for the Neurobiology of Addiction, Pain, and Emotion, Seattle, WA, USA.
Michael R BruchasDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA; University of Washington Center for the Neurobiology of Addiction, Pain, and Emotion, Seattle, WA, USA; Department of Pharmacology, University of Washington, Seattle, WA, USA. Electronic address: mbruchas@uw.edu.
Washington Center · US

Funding

Project 4_Bruchas : Circuit-level Approaches for Dissecting Approach/Avoidance Behaviors Mediated by Nociceptin Systems in MiceP50MH119467 · NIMH · MCLEAN HOSPITAL · PI PIZZAGALLI, DIEGO A · 2020 to 2024
$15.9M
University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0M
Diabetes, Obesity and Metabolism Training ProgramT32DK007247 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON, KRISTINA Marie UTZSCHNEIDER · 1986 to 2026
$10.0M
TRAINING IN THE MOLECULAR PHARMACOLOGY OF ABUSED DRUGST32DA007278 · NIDA · UNIVERSITY OF WASHINGTON · PI Susan Marie Ferguson, Paul E. M. Phillips · 1993 to 2026
$9.8M
Decoding Locus Coeruleus Neural Circuits and Signaling In Negative AffectR01MH112355 · NIMH · WASHINGTON UNIVERSITY · PI Michael R. Bruchas · 2016 to 2026
$5.3M
DISSECTING DYNORPHIN-KAPPA OPIOID MEDIATED REINSTATEMENT OF NICOTINE PREFERENCER37DA033396 · NIDA · WASHINGTON UNIVERSITY · PI Michael R. Bruchas · 2018 to 2026
$3.8M
Sleep, opiate withdrawal and the N/OFQ - NOP systemR01HL150836 · NHLBI · SRI INTERNATIONAL · PI BRUCHAS, MICHAEL R., KILDUFF, THOMAS S · 2019 to 2019
$2.0M
Optopharmacology and Sensors for Dissecting Opioid Action In VivoR61DA051489 · NIDA · UNIVERSITY OF WASHINGTON · PI BRUCHAS, MICHAEL R., GU, LIANGCAI · 2020 to 2022
$1.2M
Decoding Neuropeptide S Modulation of Reward Seeking BehaviorF32DA055480 · NIDA · UNIVERSITY OF WASHINGTON · PI GIRVEN, KASEY SHEA · 2022 to 2022
$72k
NHLBI NIH HHS R01 HL150836NIDA NIH HHS F32 DA055480NIDA NIH HHS P30 DA048736NIDA NIH HHS R37 DA033396NIDA NIH HHS R61 DA051489NIDA NIH HHS T32 DA007278NIDDK NIH HHS T32 DK007247NIMH NIH HHS P50 MH119467NIMH NIH HHS R01 MH112355
6 · The paper itself

Abstract

Neuropeptides produce robust effects on behavior across species, and recent research has benefited from advances in high-resolution techniques to investigate peptidergic transmission and expression throughout the brain in model systems. Neuropeptides exhibit distinct characteristics which includes their post-translational processing, release from dense core vesicles, and ability to activate G-protein-coupled receptors (GPCRs). These complex properties have driven the need for development of specialized tools that can sense neuropeptide expression, cell activity, and release. Current research has focused on isolating when and how neuropeptide transmission occurs, as well as the conditions in which neuropeptides directly mediate physiological and adaptive behavioral states. Here we describe the current technological landscape in which the field is operating to decode key questions regarding these dynamic neuromodulators.

Indexed as

NeuropeptidesHumansReceptors, G-Protein-CoupledNeuropeptidesReceptors, G-Protein-CoupledbiosensorGPCRimagingpeptidephotopharmacologytransmission

Identifiers

PMID36257845
PMCPMC9671847
OpenAlexW4306292615

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.