Evidence map›Paper›PMID 36257546›Full record

ArticleThe Thoracic and cardiovascular surgeon2023

Spread through Air Spaces (STAS) in Solitary Pulmonary Metastases from Colorectal Cancer (CRC).

Mohamed Anwar Haj Khalaf, Horia Sirbu, Arndt Hartmann, Abbas Agaimy, Wojciech Dudek, Mostafa Higaze, Ralf Rieker

Open access · hybridAbstract read
In one paragraph

Article in The Thoracic and cardiovascular surgeon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Pulmonary Squamous Cell Carcinoma Dissemination Through Air Spaces (STAS): Clinicopathologic Findings in Different Tumor Origins.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mohamed Anwar Haj KhalafDivision of Thoracic Surgery, Erlangen University Hospital, Erlangen, Germany.
Horia SirbuDivision of Thoracic Surgery, Erlangen University Hospital, Erlangen, Germany.
Arndt HartmannFriedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Abbas AgaimyFriedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Wojciech DudekDivision of Thoracic Surgery, Erlangen University Hospital, Erlangen, Germany.
Mostafa HigazeDivision of Thoracic Surgery, Erlangen University Hospital, Erlangen, Germany.
Ralf RiekerFriedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversitätsklinikum Erlangen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpread through air spaces (STAS) is a recently described route of tumor invasion associated with poor prognosis in primary lung cancer. Aim of this study was to investigate the presence of STAS and to assess its prognostic significance in patients undergoing pulmonary metastasectomy (PM) for solitary metastases from colorectal cancer (CRC). MATERIALS AND

methodsAll 49 CRC patients (30 male and 19 female, median age 66 years) who underwent PM between January 2008 and December 2015 were retrospectively analyzed.

resultsSTAS was identified in 26.5% (

conclusionWe identified STAS as a frequent finding in resected CRC lung metastases and found insignificant association with outcome.

Indexed as

Colorectal NeoplasmsLung NeoplasmsAgedFemaleHumansImidazolesMaleNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRetrospective StudiesTreatment OutcomeImidazolesxylometazoline

Identifiers

PMID36257546
PMCPMC9998148
OpenAlexW4306722669

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.