Evidence map›Paper›PMID 36257447›Full record

ArticleNeuropharmacology2022

Anti-seizure mechanisms of midazolam and valproate at the β2(L51M) variant of the GABA

Alibek Kuanyshbek, Meng Wang, Åsa Andersson, Marie Tuifua, Elizabeth E Palmer, Rani K Sachdev, Ting-Wei Mu, Irina Vetter, Angelo Keramidas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Alibek KuanyshbekInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Meng WangDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Åsa AnderssonInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Marie TuifuaInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Elizabeth E PalmerSydney Children's Hospital Network, Randwick Sydney Australia and School of Women's and Children's Health, UNSW Medicine, The University of New South Wales, Sydney, NSW, Australia.
Rani K SachdevSydney Children's Hospital Network, Randwick Sydney Australia and School of Women's and Children's Health, UNSW Medicine, The University of New South Wales, Sydney, NSW, Australia.
Ting-Wei MuDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Irina VetterInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia; School of Pharmacy, The University of Queensland, Woolloongabba, Queensland, 4102, Australia.
Angelo KeramidasInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia. Electronic address: a.keramidas@imb.uq.edu.au.
The University of Queensland · AUUniversity School · USUNSW Sydney · AU

Funding

Understanding GABAA receptor protein folding and misfoldingR01NS105789 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI Tingwei Mu · 2018 to 2026
$3.9M
Assembly Chaperone Complex for Membrane Proteins in the Endoplasmic ReticulumR01NS117176 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI MU, TINGWEI · 2020 to 2023
$1.6M
NINDS NIH HHS R01 NS105789NINDS NIH HHS R01 NS117176
6 · The paper itself

Abstract

Genetic sequencing is identifying an expanding number of variants of GABA

Indexed as

EpilepsyReceptors, GABA-Agamma-Aminobutyric AcidHumansMidazolamValproic Acidgamma-Aminobutyric AcidMidazolamReceptors, GABA-AValproic AcidAnti-seizure drugsEpilepsyGABA(A) receptorValproateVariants

Identifiers

PMID36257447
PMCPMC9981329
OpenAlexW4306664672

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.