ReviewNeuroscience and biobehavioral reviews2022
Pattern analysis of neuroimaging data reveals novel insights on threat learning and extinction in humans.
Review in Neuroscience and biobehavioral reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Beyond fear circuits: multiscale neurobiological architecture of panic disorder.Molecular psychiatry · 2026Pooled it
- Augmenting extinction with counterconditioning strengthens and sustains neural safety representations in PTSD.Translational psychiatry · 2026Article
- MRI markers of neuroinflammation in untreated patients with subclinical generalized anxiety disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Ventromedial prefrontal cortex activity during extinction recall suggests successful extinction learning via mental imagery.Social cognitive and affective neuroscience · 2026Article
- Encoding-Retrieval Similarity Reveals Distinct Neural Reinstatement of Safety Memories Following Counterconditioning in Posttraumatic Stress Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Current State of the Neuroscience of Fear Extinction and Its Relevance to Anxiety Disorders.Current topics in behavioral neurosciences · 2025Review
- Review
- Parkinson's disease cerebrovascular reactivity pattern: A feasibility study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Semantic structures facilitate threat memory integration throughout the medial temporal lobe and medial prefrontal cortex.Current biology : CB · 2024Article
- Acute Angiotensin II Receptor Blockade Facilitates Parahippocampal Processing During Memory Encoding in High-Trait-Anxious Individuals.Biological psychiatry global open science · 2024Article
- Introduction to the special issue on the Neurobiology of Human Fear and Anxiety.Neuroscience and biobehavioral reviews · 2023Article
- Neuroimaging of Fear Extinction.Current topics in behavioral neurosciences · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Several decades of rodent neurobiology research have identified a network of brain regions that support Pavlovian threat conditioning and extinction, focused predominately on the amygdala, hippocampus, and medial prefrontal cortex (mPFC). Surprisingly, functional magnetic resonance imaging (fMRI) studies have shown inconsistent evidence for these regions while humans undergo threat conditioning and extinction. In this review, we suggest that translational neuroimaging efforts have been hindered by reliance on traditional univariate analysis of fMRI. Whereas univariate analyses average activity across voxels in a given region, multivariate pattern analyses (MVPA) leverage the information present in spatial patterns of activity. MVPA therefore provides a more sensitive analysis tool to translate rodent neurobiology to human neuroimaging. We review human fMRI studies using MVPA that successfully bridge rodent models of amygdala, hippocampus, and mPFC function during Pavlovian learning. We also highlight clinical applications of these information-sensitive multivariate analyses. In sum, we advocate that the field should consider adopting a variety of multivariate approaches to help bridge cutting-edge research on the neuroscience of threat and anxiety.
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Registered trials
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