Evidence map›Paper›PMID 36257285›Full record

ArticleOncology2023

Genetic Variants in Histone Modification Regions Predict Clinical Outcomes of Pemetrexed Chemotherapy in Lung Adenocarcinoma.

Yong Hoon Lee, Sook Kyung Do, Shin Yup Lee, Hyo-Gyoung Kang, Jin Eun Choi, Mi Jeong Hong, Jang Hyuck Lee, Sunwoong Lee, Won Kee Lee, Ji Yun Jeong and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Yong Hoon LeeDepartments of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Sook Kyung DoDepartment of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Shin Yup LeeDepartments of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Hyo-Gyoung KangDepartment of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Jin Eun ChoiDepartment of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Mi Jeong HongDepartment of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Jang Hyuck LeeDepartment of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Sunwoong LeeDepartment of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Won Kee LeeDepartment of Medical Informatics, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Ji Yun JeongDepartment of Pathology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Kyung Min ShinDepartment of Radiology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Ji Eun ParkDepartments of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Sun Ha ChoiDepartments of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Hyewon SeoDepartments of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Seung Soo YooDepartments of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Jaehee LeeDepartments of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Seung Ick ChaDepartments of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Chang Ho KimDepartments of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Jae Yong ParkDepartments of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Kyungpook National University · KRKyungpook National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study was conducted to investigate the association between genetic variants in histone modification regions and clinical outcomes of PEM chemotherapy in patients with lung adenocarcinoma.

methodsPotentially functional SNPs were selected using integrated analysis of ChIP-seq and RNA-seq. The associations of 279 SNPs with chemotherapy response and overall survival (OS) were analyzed in 314 lung adenocarcinoma patients who underwent PEM chemotherapy.

resultsAmong the SNPs investigated, 18 were significantly associated with response to chemotherapy, while 28 with OS. Of these SNPs, rs549794A>G in an enhancer which is expected to regulate the expression of ribosomal protein S3 (RPS3) gene was significantly associated with both worse response to chemotherapy and worse OS (adjusted odds ratio = 0.59, 95% CI = 0.36-0.97, p = 0.04; adjusted hazard ratio = 1.44, 95% CI = 1.09-1.91, p = 0.01, respectively). Previous studies suggested that RPS3, a multi-functional protein with various extraribosomal activities, may play a role in chemotherapy resistance. Therefore, it is postulated that rs549794-induced change in the expression level of RPS3 may affect the response to PEM chemotherapy and consequently the survival outcomes in lung adenocarcinoma patients.

conclusionThis study suggests that genetic variants in the histone modification regions may be useful for the prediction of clinical outcomes of PEM chemotherapy in advanced lung adenocarcinoma.

Indexed as

Adenocarcinoma of LungLung NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsHistone CodeHumansPemetrexedPemetrexedChemotherapy responseGenetic variantHistone modification regionLung adenocarcinomaSurvival

Identifiers

PMID36257285
PMCPMC9932833
OpenAlexW4306721709

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.