Evidence map›Paper›PMID 36257238›Full record

ArticleJournal of diabetes and its complications2022

Femoral neck structural properties are altered in adults with type 1 diabetes.

Jake P Tinsley, R Dana Carpenter, Laura L Pyle, Janet K Snell-Bergeon, Vanessa D Sherk, Viral N Shah

Open access · greenAbstract read
In one paragraph

Article in Journal of diabetes and its complications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Trabecular bone score in adults with type 1 diabetes: a meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jake P TinsleyDepartment of Mechanical Engineering, University of Colorado Denver, Denver, CO, United States of America. Electronic address: jake.p.tinsley@ucdenver.edu.
R Dana CarpenterDepartment of Mechanical Engineering, University of Colorado Denver, Denver, CO, United States of America.
Laura L PyleDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO, United States of America; Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, United States of America.
Janet K Snell-BergeonBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, United States of America.
Vanessa D SherkDepartment of Orthopedics, University of Colorado School of Medicine, Aurora, CO, United States of America; Division of Translational and Clinical Sciences, Center for Scientific Review, National Institutes of Health, Bethesda, MD, United States of America.
Viral N ShahBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America.
University of Colorado Anschutz Medical Campus · USUniversity of Colorado Denver · US

Funding

Bone Health in Adults with Type 1 DiabetesR01DK122554 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI SHAH, VIRAL N · 2019 to 2024
$1.9M
Volumetric bone density, geometry, strength and bone tissue material properties in type 1 diabetesK23AR075099 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI SHAH, VIRAL N · 2019 to 2022
$668k
NIAMS NIH HHS K23 AR075099NIDDK NIH HHS R01 DK122554
6 · The paper itself

Abstract

aimsTo determine differences in hip geometry in adults with type 1 diabetes (T1D) compared with healthy adults without diabetes.

methodsIn this cross-sectional study, 43 adults with T1D (mean age 56 years, 84 % female, 92 % White, mean duration of diabetes of 39 years, A1c of 7.8 %) and 40 adults without diabetes (mean age 60 years, 80 % female, 77 % white) who had hip dual-energy x-ray absorptiometry (DXA) scans from previous studies were included. Areal bone mineral density (aBMD) and measures of hip structural properties at the narrow neck, intertrochanteric and femoral shaft regions of the left proximal femur were analyzed between adults with T1D and controls using linear models controlled for age, sex, and body mass index.

resultsThere were no significant differences in DXA-based aBMD at the hip (0.769 ± 0.132 vs. 0.900 ± 0.139 g/cm

conclusionsAdults with T1D have several significant differences in proximal femur morphology compared with controls. These morphological differences may adversely affect the mechanical integrity of the proximal femur, thereby contributing to an increased risk of fracture in the event of a fall.

Indexed as

Diabetes Mellitus, Type 1Femur NeckAbsorptiometry, PhotonAdultBone DensityCross-Sectional StudiesFemaleHumansMaleMiddle AgedDual-energy X-ray absorptiometryHip structural analysisType 1 diabetes

Identifiers

PMID36257238
PMCPMC10152407
OpenAlexW4296052070

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.