Evidence map›Paper›PMID 36257179›Full record

ArticleSurgical oncology2022

Prognostic value of primary tumor sidedness in patients with non-metastatic IBD related CRC - Is it the exception to the rule?

Carsten Kamphues, Jeremie H Lefevre, Jane Wang, Neda Amini, Laurent Beaugerie, Florian Kuehn, Sang Hyoung Park, Nikolaos Andreatos, Johannes C Lauscher, Diana Enea and 33 more

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Article in Surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 1 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

43 authors at 18 institutions in 8 countries.

Carsten KamphuesCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
Jeremie H LefevreSorbonne Université, Department of Digestive Surgery, Assistance Publique des Hôpitaux de Paris AP-HP, Hôpital Saint Antoine, Paris, France.
Jane WangDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Neda AminiDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Laurent BeaugerieDepartment of Gastroenterology, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Paris, France.
Florian KuehnDepartment of General, Visceral and Transplantation Surgery, Hospital of the University of Munich, Munich, Germany.
Sang Hyoung ParkDepartment of Gastroenterology and Inflammatory Bowel Disease Center, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Nikolaos AndreatosDepartment of Surgery and Department of Internal Medicine and Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Johannes C LauscherCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
Diana EneaSorbonne Université, Assistance Publique des Hôpitaux de Paris AP-HP, Department of Pathology, Saint-Antoine Hospital, Paris, France.
Kai S LehmannCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
Nicolas PeruSorbonne Université, Department of Digestive Surgery, Assistance Publique des Hôpitaux de Paris AP-HP, Hôpital Saint Antoine, Paris, France.
Benjamin WeixlerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
Julien KirchgesnerDepartment of Gastroenterology, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Paris, France.
Claudius E DegroCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
Ioannis PoziosCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
Cornelius J van BeekumDepartment of Surgery, University Hospital of Bonn, Bonn, Germany.
Sebastian SchölchDepartment of Surgery, University Medical Centre Mannheim and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Daniela ZamboninDepartment of Experimental and Clinical Medicine, IBD Unit, Careggi University Hospital, Florence, Italy.
Christian SchineisCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
Florian N LochCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
Despoina GekaFirst Department of Propaedeutic Surgery, Hippokration General Hospital of Athens, Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Maria TheoxariFirst Department of Propaedeutic Surgery, Hippokration General Hospital of Athens, Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Bin WuDepartment of General Surgery, Peking Union Medical College Hospital, Beijing, China.
Pei-Pei WangDepartment of General Surgery, Peking Union Medical College Hospital, Beijing, China.
Efstathios AntoniouSecond Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Emmanouil PikoulisSecond Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Driffa MoussataDepartment of Hepato-gastroenterology, CHU Tours, France.
George TheodoropoulosFirst Department of Propaedeutic Surgery, Hippokration General Hospital of Athens, Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Mehdi OuaissiDepartment of Digestive, Oncological, Endocrine, Hepato-Biliary and Pancreatic Surgery, Liver Transplantation, Colorectal Surgery Unit, Trousseau Hospital, Tours, France.
Hendrik SeeligerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
Yosuke InabaClinical Research Center, Chiba University Hospital, Chiba, Japan.
Stefano ScaringiDepartment of Experimental and Clinical Medicine, IBD Unit, Careggi University Hospital, Florence, Italy.
Christoph ReißfelderDepartment of Surgery, University Medical Centre Mannheim and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Tim O VilzDepartment of Surgery, University Hospital of Bonn, Bonn, Germany.
Chen LinDepartment of General Surgery, Peking Union Medical College Hospital, Beijing, China.
Suk-Kyun YangDepartment of Gastroenterology and Inflammatory Bowel Disease Center, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Katharina BeyerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
Bernhard W RenzDepartment of General, Visceral and Transplantation Surgery, Hospital of the University of Munich, Munich, Germany.
Kazunari SasakiDepartment of Surgery and Department of Internal Medicine and Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Georgios Antonios MargonisCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: margonig@mskcc.org.
Magali SvrcekSorbonne Université, Assistance Publique des Hôpitaux de Paris AP-HP, Department of Pathology, Saint-Antoine Hospital, Paris, France.
Martin E KreisCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
National and Kapodistrian University of Athens · GRAssistance Publique – Hôpitaux de Paris · FRCharité - Universitätsmedizin Berlin · DEFreie Universität Berlin · DEJohns Hopkins Medicine · USAzienda Ospedaliero-Universitaria Careggi · ITCleveland Clinic · USHôpital Saint-Antoine · FRPeking Union Medical College Hospital · CNUniversity Hospital Bonn · DEAsan Medical Center · KRChiba University Hospital · JPHumboldt-Universität zu Berlin · DELMU Klinikum · DEMünchen Klinik · DEUniversity Hospital Heidelberg · DEUniversity Medical Centre Mannheim · DEUniversity of Ulsan · KR

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundAlthough primary tumor sidedness (PTS) has a known prognostic role in sporadic colorectal cancer (CRC), its role in Inflammatory Bowel Disease related CRC (IBD-CRC) is largely unknown. Thus, we aimed to evaluate the prognostic role of PTS in patients with IBD-CRC.

methodsAll eligible patients with surgically treated, non-metastatic IBD-CRC were retrospectively identified from institutional databases at ten European and Asian academic centers. Long term endpoints included recurrence-free (RFS) and overall survival (OS). Multivariable Cox proportional hazard regression as well as propensity score analyses were performed to evaluate whether PTS was significantly associated with RFS and OS.

resultsA total of 213 patients were included in the analysis, of which 32.4% had right-sided (RS) tumors and 67.6% had left-sided (LS) tumors. PTS was not associated with OS and RFS even on univariable analysis (5-year OS for RS vs LS tumors was 68.0% vs 77.3%, respectively, p = 0.31; 5-year RFS for RS vs LS tumors was 62.8% vs 65.4%, respectively, p = 0.51). Similarly, PTS was not associated with OS and RFS on propensity score matched analysis (5-year OS for RS vs LS tumors was 82.9% vs 91.3%, p = 0.79; 5-year RFS for RS vs LS tumors was 85.1% vs 81.5%, p = 0.69). These results were maintained when OS and RFS were calculated in patients with RS vs LS tumors after excluding patients with rectal tumors (5-year OS for RS vs LS tumors was 68.0% vs 77.2%, respectively, p = 0.38; 5-year RFS for RS vs LS tumors was 62.8% vs 59.2%, respectively, p = 0.98).

conclusionsIn contrast to sporadic CRC, PTS does not appear to have a prognostic role in IBD-CRC.

Indexed as

Colorectal NeoplasmsInflammatory Bowel DiseasesRectal NeoplasmsHumansPrognosisRetrospective StudiesCRCIBDTumor laterality

Identifiers

PMID36257179
PMCPMC10266238
OpenAlexW4304687463

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.