Evidence map›Paper›PMID 36256822›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Photoacoustic image-guided biomimetic nanoparticles targeting rheumatoid arthritis.

Jianhai Chen, Silue Zeng, Qiang Xue, Yuchuan Hong, Liangjian Liu, Liang Song, Chihua Fang, Hai Zhang, Benguo Wang, Adam C Sedgwick and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 71 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Jianhai ChenResearch Laboratory for Biomedical Optics and Molecular Imaging, CAS Key Laboratory of Health Informatics, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Silue ZengResearch Laboratory for Biomedical Optics and Molecular Imaging, CAS Key Laboratory of Health Informatics, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Qiang XueResearch Laboratory for Biomedical Optics and Molecular Imaging, CAS Key Laboratory of Health Informatics, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Yuchuan HongThe Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Liangjian LiuResearch Laboratory for Biomedical Optics and Molecular Imaging, CAS Key Laboratory of Health Informatics, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Liang SongResearch Laboratory for Biomedical Optics and Molecular Imaging, CAS Key Laboratory of Health Informatics, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Chihua FangDepartment of Hepatobiliary Surgery I, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
Hai ZhangDepartment of Ultrasound, Shenzhen People's Hospital, The Second Clinical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518020, China.
Benguo WangRehabilitation Department of Longgang District People's Hospital of Shenzhen, The Second Affiliated Hospital of the Chinese University of Hong Kong, Shenzhen 518172, China.
Adam C SedgwickChemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom.
Peng ZhangCenter for Translational Medicine Research and Development, Shenzhen Engineering Research Center for Medical Bioactive Materials, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen 518055, China.ORCID 0000-0003-3706-3833
Jonathan L SesslerDepartment of Chemistry, University of Texas at Austin, Austin, TX 78712-1224.ORCID 0000-0002-9576-1325
Chengbo LiuResearch Laboratory for Biomedical Optics and Molecular Imaging, CAS Key Laboratory of Health Informatics, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Jingqin ChenResearch Laboratory for Biomedical Optics and Molecular Imaging, CAS Key Laboratory of Health Informatics, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Chinese Academy of Sciences · CNJinan University · CNChinese University of Hong Kong, Shenzhen · CNShenzhen Institutes of Advanced Technology · CNThe University of Texas at Austin · USUniversity of Oxford · GBZhujiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The high level of reactive oxygen species (ROS) in the rheumatoid arthritis (RA) microenvironment (RAM) and its persistent inflammatory nature can promote damage to joints, bones, and the synovium. Targeting strategies that integrate effective RAM regulation with imaging-based monitoring could lead to improvements in the diagnosis and treatment of RA. Here, we report the combined use of small interfering RNAs (siRNAs

Indexed as

Arthritis, RheumatoidNanoparticlesAnimalsBiomimeticsCytokinesFerrocyanidesInterleukin-6MiceReactive Oxygen SpeciesRNA, Small InterferingTumor Necrosis Factor-alphaX-Ray MicrotomographyCytokinesferric ferrocyanideFerrocyanidesInterleukin-6Reactive Oxygen SpeciesRNA, Small InterferingTumor Necrosis Factor-alphabiomimetic nanoparticlesphotoacousticrheumatoid arthritissmall interfering RNAtargeted imaging

Identifiers

PMID36256822
PMCPMC9618076
OpenAlexW4306735360

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.