ArticleProceedings of the National Academy of Sciences of the United States of America2022
Multiple forms of working memory emerge from synapse-astrocyte interactions in a neuron-glia network model.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Targeted neuronal stimulation modulates working memory via astrocytic interactions: Insights from a spiking neuron-astrocyte model.iScience · 2026Article
- Differential roles of frontoparietal regions in working memory and decision-making.bioRxiv : the preprint server for biology · 2026Article
- Astrocyte-mediated higher-order control of synaptic plasticity.Communications biology · 2026Article
- Astrocytes and neurons exhibit partially shared but distinct composite receptive fields for natural stimuli.Journal of neurophysiology · 2026Article
- Astrocyte-Mediated Plasticity: Multi-Scale Mechanisms Linking Synaptic Dynamics to Learning and Memory.Cells · 2025Review
- Review
- Modeling neuron-astrocyte interactions in neural networks using distributed simulation.PLoS computational biology · 2025Article
- Multistable Synaptic Plasticity Induces Memory Effects and Cohabitation of Chimera and Bump States in Leaky Integrate-and-Fire Networks.Entropy (Basel, Switzerland) · 2025Article
- Biological detail and graph structure in network neuroscience.Frontiers in network physiology · 2025Review
- Astrocyte-mediated neuronal irregularities and dynamics: the complexity of the tripartite synapse.Biological cybernetics · 2024Article
- Neuron-Glial Interactions: Implications for Plasticity, Behavior, and Cognition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Astrocytes as a mechanism for contextually-guided network dynamics and function.PLoS computational biology · 2024Article
- Complex Regulation of Protocadherin Epigenetics on Aging-Related Brain Health.medRxiv : the preprint server for health sciences · 2024Article
- Random fluctuations and synaptic plasticity enhance working memory activities in the neuron-astrocyte network.Cognitive neurodynamics · 2024Article
- Astrocytes and Memory: Implications for the Treatment of Memory-related Disorders.Current neuropharmacology · 2024Review
- Astrocyte's self-repairing characteristics improve working memory in spiking neuronal networks.iScience · 2023Article
- Building transformers from neurons and astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes.Entropy (Basel, Switzerland) · 2023Article
- Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023Article
- Multiple forms of working memory emerge from synapse-astrocyte interactions in a neuron-glia network model.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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2 authors.
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Abstract
Persistent activity in populations of neurons, time-varying activity across a neural population, or activity-silent mechanisms carried out by hidden internal states of the neural population have been proposed as different mechanisms of working memory (WM). Whether these mechanisms could be mutually exclusive or occur in the same neuronal circuit remains, however, elusive, and so do their biophysical underpinnings. While WM is traditionally regarded to depend purely on neuronal mechanisms, cortical networks also include astrocytes that can modulate neural activity. We propose and investigate a network model that includes both neurons and glia and show that glia-synapse interactions can lead to multiple stable states of synaptic transmission. Depending on parameters, these interactions can lead in turn to distinct patterns of network activity that can serve as substrates for WM.
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