ArticlePLoS pathogens2022
Combinatorial interactions between viral proteins expand the potential functional landscape of the tomato yellow leaf curl virus proteome.
Article in PLoS pathogens, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- The divergent V2 protein encoded by parsley yellow leaf curl virus is a suppressor of transcriptional and post-transcriptional gene silencing and a potential symptom determinant.BMC plant biology · 2026Article
- Intra-viral protein-protein interactions could expand the functional portfolio of C4 in okra-infecting geminiviruses.Virus research · 2026Article
- High-Throughput Screening of Antiviral Agents Using the Fluorescence-Based Local Lesion Inspection Assay.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Viral proteins as discovery tools for cell biology: The case of the geminivirus-encoded C4.PLoS pathogens · 2026Article
- Virulence determinant of Senecavirus A: 3C protein functions as a protease to cleave viral polyprotein and host factors.Virulence · 2025Review
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- Cucumber green mottle mosaic virus encodes additional small proteins with specific subcellular localizations and virulence function.Science China. Life sciences · 2025Article
- Subcellular Localization of Geminivirus Proteins by Laser Scanning Confocal Microscopy.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Characterisation of a Betasatellite Associated With Tomato Yellow Leaf Curl Guangdong Virus and Discovery of an Unusual Modulation of Virus Infection Associated With C4 Protein.Molecular plant pathology · 2025Article
- Cell Fractionation and the Identification of Host Proteins Involved in Plant-Virus Interactions.Pathogens (Basel, Switzerland) · 2024Review
- Review
- Role of Plant Virus Movement Proteins in Suppression of Host RNAi Defense.International journal of molecular sciences · 2023Review
- Article
- Split-luciferase Complementation Imaging Assay to Study Protein-protein Interactions inBio-protocol · 2021Article
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Authors and funding
17 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viruses manipulate the cells they infect in order to replicate and spread. Due to strict size restrictions, viral genomes have reduced genetic space; how the action of the limited number of viral proteins results in the cell reprogramming observed during the infection is a long-standing question. Here, we explore the hypothesis that combinatorial interactions may expand the functional landscape of the viral proteome. We show that the proteins encoded by a plant-infecting DNA virus, the geminivirus tomato yellow leaf curl virus (TYLCV), physically associate with one another in an intricate network, as detected by a number of protein-protein interaction techniques. Importantly, our results indicate that intra-viral protein-protein interactions can modify the subcellular localization of the proteins involved. Using one particular pairwise interaction, that between the virus-encoded C2 and CP proteins, as proof-of-concept, we demonstrate that the combination of viral proteins leads to novel transcriptional effects on the host cell. Taken together, our results underscore the importance of studying viral protein function in the context of the infection. We propose a model in which viral proteins might have evolved to extensively interact with other elements within the viral proteome, enlarging the potential functional landscape available to the pathogen.
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