Evidence map›Paper›PMID 36255603›Full record

ReviewCurrent oncology reports2022

Immune Checkpoint Inhibitors and Novel Immunotherapy Approaches for Breast Cancer.

Mónica Cejuela, Andrea Vethencourt, Sonia Pernas

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current oncology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Identification of SMC2 and SMC4 as prognostic markers in breast cancer through bioinformatics analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mónica CejuelaDepartment of Medical Oncology, Institut Catala d'Oncologia (ICO) - L'Hospitalet de Llobregat, Gran Via de l'Hospitalet 199-203, Barcelona, Spain.ORCID 0000-0002-3894-0765
Andrea VethencourtDepartment of Medical Oncology, Institut Catala d'Oncologia (ICO) - L'Hospitalet de Llobregat, Gran Via de l'Hospitalet 199-203, Barcelona, Spain.
Sonia PernasDepartment of Medical Oncology, Institut Catala d'Oncologia (ICO) - L'Hospitalet de Llobregat, Gran Via de l'Hospitalet 199-203, Barcelona, Spain. spernas@iconcologia.net.ORCID 0000-0002-1485-5080

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewTo critically review the existing evidence on immune checkpoint inhibitors (ICIs) in early-stage and metastatic breast cancer and discuss emerging strategies in the different breast cancer subtypes. RECENT

findingsImmunotherapy has become one of the major milestones in contemporary oncology, revolutionizing the treatment of multiple solid tumors. ICI agents combined with chemotherapy have demonstrated significant efficacy in both early-stage and metastatic triple-negative breast cancer. However, only a subgroup of patients responds to those agents and some associated toxicities, although infrequent, can be life-disabling. Emerging data from immunotherapy studies in advanced hormone receptor-positive (HR +) breast cancer as well as HER2-positive disease are arising with mixed results. Although breast cancer has not classically been considered a hot tumor, ICIs have proven to be effective in a subset of breast cancer patients. However, much remains to be learned, and the identification of new biomarkers beyond PD-L1 expression is essential not only to improve the efficacy of ICI but also to identify patients who can avoid them, together with their toxicities and costs.

Indexed as

Immune Checkpoint InhibitorsTriple Negative Breast NeoplasmsB7-H1 AntigenHumansImmunologic FactorsImmunotherapyB7-H1 AntigenImmune Checkpoint InhibitorsImmunologic FactorsBiomarkersBreast cancerEarly stageHER2-positive breast cancerHormone receptor–positive breast cancerImmune checkpoint blockadeImmune checkpoint inhibitorsImmune responseImmunotherapyMetastatic breast cancerPD-1PD-L1Triple-negative breast cancerTumor-infiltrating lymphocytesTumor mutational burdenTumor subtype

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.