ArticleClinical oral investigations2023
Tissue integration and biodegradation of soft tissue substitutes with and without compression: an experimental study in the rat.
Article in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Collagen Substitutes in Oral Soft Tissue Augmentation: An In Vitro-Ex Vivo Study on Expansion and Elasticity.Clinical and experimental dental research · 2026Article
- Porcine Collagen Matrices for the Treatment of Multiple Gingival Recessions: A Case Report With 4 Years Follow-Up.Case reports in dentistry · 2026Article
- Soft-Tissue Volume Augmentation at Dental Implant Placement Using Collagen-Based Matrix Characterized by Oriented Open Pore Structure: A Retrospective Study with a Median Follow-Up of 17 Months.Bioengineering (Basel, Switzerland) · 2025Article
- Association of flap tension with flap design and graft volume in soft tissue augmentation: a cadaveric study in pigs.Journal of periodontal & implant science · 2025Article
- 3D surface defect map for assessing buccolingual profile of single tooth gaps following alveolar ridge preservation.Clinical implant dentistry and related research · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesTo analyze the influence of compression on tissue integration and degradation of soft tissue substitutes. MATERIAL AND
methodsSix subcutaneous pouches in twenty-eight rats were prepared and boxes made of Al
resultsThe area fraction of fibroblasts increased in all groups over time. At 12 weeks, the densely compressed materials FG4 (1.1%), MGA4 (1.7%), and MGA2 (2.5%) obtained lower values as compared to the other groups, ranging between 4.7 (E2) and 6.5% (MG). Statistically significant differences (p ≤ 0.05) were observed between groups FG4 vs MG/FG2/E/E4 as well as between MGA4 vs MG/FG2/E/E4 and E vs MGA2.
conclusionsHigher levels of compression led to delayed tissue integration. The effect of different compression levels was more distinct when compared to the differences between the materials. CLINICAL RELEVANCE: All biomaterials demonstrated tissue integration and a minimal concomitant inflammatory reaction. Clinically, it might be more favorable to obtain a sufficient flap release or to reduce the material size to improve the tissue integration processes.
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