Evidence map›Paper›PMID 36255457›Full record

ArticlePediatric radiology2023

Usefulness of central radiologic review in clinical trials of children with hepatoblastoma.

Osamu Miyazaki, Eiji Oguma, Masanori Nishikawa, Yutaka Tanami, Takahiro Hosokawa, Masahiro Kitami, Hidekazu Aoki, Shinya Hattori, Ken Motoori, Kenichiro Watanabe and 6 more

Abstract read
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In one paragraph

Article in Pediatric radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Hepatoblastoma.Nature reviews. Disease primers · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Osamu MiyazakiRadiology Committee, Pediatric Liver Tumor Group, Japan Children's Cancer Group, Tokyo, Japan. miyazaki-o@ncchd.go.jp.ORCID 0000-0002-1793-4892
Eiji OgumaRadiology Committee, Pediatric Liver Tumor Group, Japan Children's Cancer Group, Tokyo, Japan.
Masanori NishikawaRadiology Committee, Pediatric Liver Tumor Group, Japan Children's Cancer Group, Tokyo, Japan.
Yutaka TanamiRadiology Committee, Pediatric Liver Tumor Group, Japan Children's Cancer Group, Tokyo, Japan.
Takahiro HosokawaRadiology Committee, Pediatric Liver Tumor Group, Japan Children's Cancer Group, Tokyo, Japan.ORCID 0000-0001-9523-4077
Masahiro KitamiRadiology Committee, Pediatric Liver Tumor Group, Japan Children's Cancer Group, Tokyo, Japan.ORCID 0000-0003-3116-5441
Hidekazu AokiRadiology Committee, Pediatric Liver Tumor Group, Japan Children's Cancer Group, Tokyo, Japan.ORCID 0000-0002-6870-3031
Shinya HattoriRadiology Committee, Pediatric Liver Tumor Group, Japan Children's Cancer Group, Tokyo, Japan.ORCID 0000-0003-4766-6355
Ken MotooriRadiology Committee, Pediatric Liver Tumor Group, Japan Children's Cancer Group, Tokyo, Japan.
Kenichiro WatanabeLiver Tumor Committee, Japan Children's Cancer Group (JCCG), Hiroshima, Japan.ORCID 0000-0002-8892-3082
Kohmei IdaLiver Tumor Committee, Japan Children's Cancer Group (JCCG), Hiroshima, Japan.
Tomoro HishikiLiver Tumor Committee, Japan Children's Cancer Group (JCCG), Hiroshima, Japan.ORCID 0000-0002-2515-1054
Masayuki KitamuraDepartment of Radiology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, Japan.
Kumiko NozawaRadiology Committee, Japan Children's Cancer Group, Tokyo, Japan.
Tetsuya TakimotoDepartment of Childhood Cancer Data Management, National Center for Child Health and Development, Tokyo, Japan.
Eiso HiyamaLiver Tumor Committee, Japan Children's Cancer Group (JCCG), Hiroshima, Japan.ORCID 0000-0001-9179-5037
Children's Oncology Group · CHChildren's Cancer Association of Japan · JPHiroshima University · JPKanagawa Children's Medical Center · JPNational Center For Child Health and Development · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNo previous research papers have reported a comparative survey of local radiologic diagnoses and central review in children with hepatoblastoma.

objectiveTo evaluate the utility of central review of children with hepatoblastoma enrolled in a clinical trial. MATERIALS AND

methodsThe study included 91 children enrolled in a clinical trial conducted by the Japanese Study Group for Pediatric Liver Tumor. We compared the results of the initial pre-treatment extent of tumor (PRETEXT) disease staging performed at local sites with the results obtained on central review to determine the concurrence rates for tumor staging and additional criteria.

resultsThe concurrence rate for PRETEXT staging was 70%. As the stage increased, the concurrence rate decreased. Using additional criteria, central review identified 143 lesions (157.1%), about 1.8 times higher than the number identified for the local site diagnoses. The additional criterion found most often on central review was "multifocal lesion" (n=19). The concurrence rate for lung metastases was high. However, our central review found many false-positive assertions of hepatic vein lesions, portal vein invasion and extrahepatic lesions among the local site diagnoses.

conclusionIn a clinical trial of hepatoblastoma, central review provided a more precise diagnosis than local site diagnoses with respect to severe PRETEXT stages III and IV cases and other cases including hepatic and portal vein invasion. The central review process appears to be effective and essential for improving the quality of clinical trials.

Indexed as

HepatoblastomaLiver NeoplasmsLung NeoplasmsChildHumansInfantNeoplasm StagingTreatment OutcomeCentral reviewChildrenCriteriaDiagnosisHepatoblastomaLiverPre-treatment extent of tumorStagingTumor

Identifiers

PMID36255457
OpenAlexW4306671438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.