Evidence map›Paper›PMID 36255356›Full record

ArticleBiological research for nursing2023

A Pilot Study of Associations Between the Occurrence of Palpitations and Cytokine Gene Variations in Women Prior to Breast Cancer Surgery.

Ying Sheng, Janet S Carpenter, Brenda J Smith, Steven M Paul, Michelle Melisko, Javid Moslehi, Jon D Levine, Yvette P Conley, Kord M Kober, Christine Miaskowski

Abstract read
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In one paragraph

Article in Biological research for nursing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ying ShengSchool of Nursing, Vanderbilt University, Nashville, TN, USA.
Janet S CarpenterSchool of Medicine, Indiana University, Indianapolis, IN, USA.
Brenda J SmithSchool of Medicine, Indiana University, Indianapolis, IN, USA.
Steven M PaulSchool of Nursing, University of California, San Francisco, CA, USA.
Michelle MeliskoSchool of Nursing, University of California, San Francisco, CA, USA.
Javid MoslehiSchool of Nursing, University of California, San Francisco, CA, USA.
Jon D LevineSchool of Nursing, University of California, San Francisco, CA, USA.
Yvette P ConleySchool of Nursing, 6614University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-1784-6067
Kord M KoberSchool of Nursing, University of California, San Francisco, CA, USA.ORCID 0000-0001-9732-3321
Christine MiaskowskiSchool of Nursing, University of California, San Francisco, CA, USA.ORCID 0000-0001-5170-2027

Funding

Symptom Management After Breast Cancer SurgeryR01CA107091 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2003 to 2008
$4.5M
Long-term Arm Morbidity Following Breast Cancer TreatmentR01CA118658 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2006 to 2010
$3.5M
NCI NIH HHS R01 CA107091NCI NIH HHS R01 CA118658
6 · The paper itself

Abstract

objectivesPalpitations are common and have a negative impact on women's quality of life. While evidence suggests that inflammatory mechanisms may play a role in the development of palpitations, no studies have evaluated for this association in patients with breast cancer who report palpitations prior to surgery. The purpose of this pilot study was to evaluate for associations between the occurrence of palpitations and single nucleotide polymorphisms (SNPs) in genes for pro- and anti-inflammatory cytokines, their receptors, and transcriptional regulators.

methodsPatients were recruited prior to surgery and completed a self-report questionnaire on the occurrence of palpitations. Genotyping of SNPs in cytokine genes was performed using a custom array. Multiple logistic regression analyses were done to identify associations between the occurrence of palpitations and SNPs in fifteen candidate genes.

resultsOf the 82 SNPs evaluated in the bivariate analyses, eleven SNPs in 6 genes were associated with the occurrence of palpitations. After controlling for functional status, the occurrence of back pain, and self-reported and genomic estimates of race/ethnicity, 3 SNPs in 3 different genes (i.e., interleukin (IL) 1-beta (IL1B) rs1143643, IL10 rs3024505, IL13 rs1295686) were associated with the occurrence of palpitations prior to surgery (all

conclusionsWhile these preliminary findings warrant replication, they suggest that inflammatory mechanisms may contribute to the subjective sensation of palpitations in women prior to breast cancer surgery.

Indexed as

Arrhythmias, CardiacBreast NeoplasmsCytokinesFemaleGenetic Predisposition to DiseaseGenotypeHumansPilot ProjectsPolymorphism, Single NucleotideQuality of LifeCytokinesbreast cancercardio-oncologycytokinesinterleukinsmenopausal symptomspalpitationssingle nucleotide polymorphisms

Identifiers

PMID36255356
PMCPMC10236444

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.