Evidence map›Paper›PMID 36255333›Full record

ArticleMicrobiology spectrum2022

A Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry Direct-from-Urine-Specimen Diagnostic for Gram-Negative Pathogens.

Hyojik Yang, Richard D Smith, Kylie P Sumner, David R Goodlett, J Kristie Johnson, Robert K Ernst

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Clinical application of MALDI-TOF MS for direct and rapid pathogen identification: a comprehensive review focusing on bloodstream infections and sterile body fluids.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. DivergentmBio · 2024
    Article
  8. Article
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  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Hyojik Yang *Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimoregrid.411024.2, Maryland, USA.
Richard D Smith *Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimoregrid.411024.2, Maryland, USA.ORCID 0000-0002-1908-3083
Kylie P SumnerDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimoregrid.411024.2, Maryland, USA.
David R GoodlettDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada.
J Kristie Johnson *Department of Pathology, School of Medicine, University of Maryland, Baltimoregrid.411024.2, Maryland, USA.
Robert K Ernst *Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimoregrid.411024.2, Maryland, USA.ORCID 0000-0001-5016-8694
University of Maryland, Baltimore · USUniversity of Victoria · CA

Funding

Colistin-resistant Acinetobacter baumanniiR01AI104895 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI, ERNST, ROBERT K · 2014 to 2024
$4.2M
MS Diagnostic Bacterial Identification LibraryR01AI147314 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI ERNST, ROBERT K, GOODLETT, DAVID ROBINSON · 2020 to 2024
$2.3M
NIAID NIH HHS R01 AI104895NIAID NIH HHS R01 AI147314
6 · The paper itself

Abstract

Urinary tract infections (UTIs) pose a major public health burden. The vast majority of UTIs are caused by Gram-negative bacteria. Current culture-based pathogen identification methods may require up to 24 to 48 h of incubation. In this study, we developed and evaluated a method for Gram-negative pathogen identification direct from urine, without culture, via matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) in approximately 1 h. Urine samples were collected (

Indexed as

Urinary Tract InfectionsBacteriaGram-Negative BacteriaHumansLaboratoriesSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionizationfast lipid analysis techniqueGram-negative bacterialipid AMALDI-TOF mass spectrometryMALDI-TOF MSurinary tract infectionUTI

Identifiers

PMID36255333
PMCPMC9769899
OpenAlexW4306704105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.