ArticleActa radiologica (Stockholm, Sweden : 1987)2023
Virtual monoenergetic images by spectral detector computed tomography may improve image quality and diagnostic ability for ischemic lesions in acute ischemic stroke.
Article in Acta radiologica (Stockholm, Sweden : 1987), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 4 citations in OpenAlex.
- Optimization of Posterior Fossa Image Quality Using Virtual Monoenergetic Reconstructions from Dual-Layer Spectral CT.Tomography (Ann Arbor, Mich.) · 2026Article
- Spectral CTA-based quantitative differentiation of infarcted and non-infarcted ASPECTS regions in acute stroke.European radiology experimental · 2026Article
- pH-sensitive probes for ischemic stroke: advancing early detection and accurate grading.Frontiers in molecular biosciences · 2026Review
- Acute stroke diagnosis: diagnostic efficacy of dual-layer spectral computed tomography for non-contrast ischemic sign detection.Quantitative imaging in medicine and surgery · 2025Article
- Imaging of hypodense gliotic lesions in photon counting computed tomography using virtual monoenergetic images.The neuroradiology journal · 2024Article
- Clinical Applications of Dual-Energy Computed Tomography for Acute Ischemic Stroke.Stroke (Hoboken, N.J.) · 2024Review
- Metal artifact reduction by virtual monoenergetic reconstructions from spectral brain CT.European journal of radiology open · 2023Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute ischemic lesions are challenging to detect by conventional computed tomography (CT). Virtual monoenergetic images may improve detection rates by increased tissue contrast. PURPOSE: To compare the ability to detect ischemic lesions of virtual monoenergetic with conventional images in patients with acute stroke. MATERIAL AND
methodsWe included consecutive patients at our center that underwent brain CT in a spectral scanner for suspicion of acute stroke, onset <12 h, with or without (negative controls) a confirmed cortical ischemic lesion in the initial scan or a follow-up CT or magnetic resonance imaging. Attenuation was measured in predefined areas in ischemic gray (guided by follow-up exams), normal gray, and white matter in conventional images and retrieved in spectral diagrams for the same locations in monoenergetic series at 40-200 keV. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated. Visual assessment of diagnostic measures was performed by independent review by two neuroradiologists blinded to reconstruction details.
resultsIn total, 29 patients were included (January 2018 to July 2019). SNR was higher in virtual monoenergetic compared to conventional images, significantly at 60-150 keV. CNR between ischemic gray and normal white matter was higher in monoenergetic images at 40-70 keV compared to conventional images. Virtual monoenergetic images received higher scores in overall image quality. The sensitivity for diagnosing acute ischemia was 93% and 97%, respectively, for the reviewers, compared to 55% of the original report based on conventional images.
conclusionVirtual monoenergetic reconstructions of spectral CIs may improve image quality and diagnostic ability in stroke assessment.
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