ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023
Racial, Ethnic, and Socioeconomic Differences in a Deficit Accumulation Frailty Index in the Multiethnic Cohort Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Interplay between frailty and cardiometabolic disorders: from pathophysiology to clinical implications.Cardiovascular diabetology · 2025Pooled it
- Associations Between Deficit Accumulation Frailty and Baseline Markers of Lifestyle in the U.S. POINTER Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Trial
- Epigenetic aging markers in the association between frailty and mortality among U.S. adults.BMC medicine · 2026Article
- Neighborhood Deprivation Associated with Impaired Sit-to-Stand Performance in Middle-Aged and Older Adults: A Cross-Sectional Analysis with Clinical Implications.Healthcare (Basel, Switzerland) · 2026Article
- Associations of neurodegenerative and cerebrovascular neuropathology with frailty in a diverse sample.Acta neuropathologica communications · 2025Article
- Frailty-free life expectancy and its association with socio-economic characteristics: an analysis of the English Longitudinal Study of Ageing cohort study.BMC medicine · 2025Article
- The development of frailty trajectories in world trade center general responders and the association with World Trade Center Exposure.The Journal of frailty & aging · 2025Article
- Dietary intake of live microbes and its association with frailty in older adults: a NHANES analysis (1999-2018).BMC geriatrics · 2025Article
- Body mass index, frailty, and outcomes in heart failure with preserved ejection fraction.ESC heart failure · 2024Article
- Correlates of frailty in older female cancer survivors.Journal of geriatric oncology · 2024Article
- How to construct a frailty index from an existing dataset in 10 steps.Age and ageing · 2023Article
- Association between frailty and chronic constipation and chronic diarrhea among American older adults: National Health and Nutrition Examination Survey.BMC geriatrics · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundFrailty status has been sparsely studied in some groups including Native Hawaiians and Asian Americans.
methodsWe developed a questionnaire-based deficit accumulation frailty index (FI) in the Multiethnic Cohort (MEC) and examined frailty status (robust, FI 0 to <0.2, prefrail, FI 0.2 to <0.35, and frail FI ≥ 0.35) among 29 026 men and 40 756 women.
resultsAfter adjustment for age, demographic, lifestyle factors, and chronic conditions, relative to White men, odds of being frail was significantly higher (34%-54%) among African American, Native Hawaiian, and other Asian American men, whereas odds was significantly lower (36%) in Japanese American men and did not differ in Latino men. However, among men who had high school or less, none of the groups displayed significantly higher odds of prefrail or frail compared with White men. Relative to White women, odds of being frail were significantly higher (14%-33%) in African American and Latino women, did not differ for other Asian American women and lower (14%-36%) in Native Hawaiian and Japanese American women. These racial and ethnic differences in women were observed irrespective of education. Risk of all-cause mortality was higher in prefrail and frail men than robust men (adjusted hazard ratio [HR] = 1.69, 1.59-1.81; HR = 3.27, 3.03-3.53); results were similar in women. All-cause mortality was significantly positively associated with frailty status and frailty score across all sex, race, and ethnic groups.
conclusionsFrailty status differed significantly by race and ethnicity and was consistently associated with all-cause mortality. The FI may be a useful tool for aging studies in this multiethnic population.
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