ArticleeLife2022
A phenotype-based forward genetic screen identifies
Open access · goldAbstract read
In one paragraph
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Construction of a Zebrafish Model of Cardiac Hypertrophy Caused by ATIC Gene Deletion and Preliminary Exploration of Aerobic Exercise Improvement.International journal of molecular sciences · 2025Article
- Cardiogenic and chronobiological mechanisms in seizure-induced sinus arrhythmias.PLoS computational biology · 2025Article
- Review
- Dominantly inherited muscle disorders: understanding their complexity and exploring therapeutic approaches.Disease models & mechanisms · 2024Review
- Circadian regulation of sinoatrial nodal cell pacemaking function: Dissecting the roles of autonomic control, body temperature, and local circadian rhythmicity.PLoS computational biology · 2024Article
- Forward genetic screen using a gene-breaking trap approach identifies a novel role ofFrontiers in cell and developmental biology · 2024Article
- DNAJB6 isoform specific knockdown: Therapeutic potential for limb girdle muscular dystrophy D1.Molecular therapy. Nucleic acids · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 9 institutions in 2 countries.
Yonghe DingDepartment of Biochemistry and Molecular Biology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, United States.ORCID 0000-0002-4531-1721
Di LangDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, United States.
Jianhua YanDepartment of Biochemistry and Molecular Biology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, United States.
Haisong BuDepartment of Biochemistry and Molecular Biology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, United States.
Hongsong LiDepartment of Biochemistry and Molecular Biology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, United States.
Kunli JiaoDepartment of Biochemistry and Molecular Biology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, United States.
Jingchun YangDepartment of Biochemistry and Molecular Biology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, United States.
Haibo NiDepartment of Pharmacology, University of California, Davis, Davis, United States.
Stefano MorottiDepartment of Pharmacology, University of California, Davis, Davis, United States.
Tai LeDepartment of Biomedical Engineering, University of California, Irvine, Irvine, United States.
Karl J ClarkDepartment of Biochemistry and Molecular Biology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, United States.ORCID 0000-0002-9637-0967
Jenna PortDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, United States.
Stephen C EkkerDepartment of Biochemistry and Molecular Biology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, United States.ORCID 0000-0003-0726-4212
Hung CaoDepartment of Biomedical Engineering, University of California, Irvine, Irvine, United States.
Yuji ZhangDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, United States.
Jun WangDepartment of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, United States.
Eleonora GrandiDepartment of Pharmacology, University of California, Davis, Davis, United States.
Zhiqiang LiThe Affiliated Hospital of Qingdao University & The Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, Qingdao, China.
Yongyong ShiThe Affiliated Hospital of Qingdao University & The Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, Qingdao, China.
Yigang LiDivision of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School Of Medicine, Shanghai, China.
Alexey V GlukhovDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, United States.
Xiaolei XuDepartment of Biochemistry and Molecular Biology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, United States.ORCID 0000-0002-4928-3422
Mayo Clinic · USQingdao University · CNUniversity of California, Davis · USUniversity of Wisconsin–Madison · USUniversity of California, Irvine · USShanghai University · CNThe University of Texas Health Science Center at Houston · USUniversity of Maryland, Baltimore · USXinHua Hospital · CN
Funding
Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI MARK MERCOLA · 2019 to 2026
$21.1MSystematic Vertebrate Functional GenomicsR01GM063904 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI EKKER, STEPHEN CARL · 2001 to 2025
$10.7MEpicardial remodeling in cardiomyopathy and cardiac agingR01HL107304 · NHLBI · MAYO CLINIC ROCHESTER · PI Xiaolei Xu · 2011 to 2026
$6.6MDevelopment of the Predictive NeuroCardiovascular SimulatorOT2OD026580 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, GRANDI, ELEONORA · 2018 to 2021
$5.7MSex-specific arrhythmogenic mechanisms of atrial fibrillationR01HL131517 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2016 to 2026
$5.0MFunctional Microdomains in the Heart's Pacemaker: A New Dimension of Cardiac RemodelingR01HL141214 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Alexey V Glukhov · 2018 to 2026
$3.8MConditional genetics and precision genome editing resources for ZebrafishR24OD036201 · OD · IOWA STATE UNIVERSITY · PI KARL J CLARK, Stephen Carl Ekker · 2024 to 2026
$3.0MGenetic dissection of Cardiac Conduction System homeostasis and RepairR01HL142704 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Jun Wang · 2020 to 2026
$3.0MCloud-based High-throughput Acquisition and Analytics of Zebrafish Electrocardiogram for Cardiac Studies and Drug DevelopmentR44OD024874 · OD · SENSORIIS, INC. · PI CAO, HUNG, LAU, MICHAEL P.H. · 2020 to 2021
$1.5MModeling of subcellular signaling crosstalk in failing myocytesR00HL138160 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MOROTTI, STEFANO · 2020 to 2022
$722kSystematic Vertebrate Functional GenomicsR56GM063904 · NIGMS · MAYO CLINIC ROCHESTER · PI EKKER, STEPHEN CARL · 2009 to 2010
$611kNHLBI NIH HHS P01 HL141084NHLBI NIH HHS R00 HL138160NHLBI NIH HHS R01 HL107304NHLBI NIH HHS R01 HL131517NHLBI NIH HHS R01 HL141214NHLBI NIH HHS R01 HL142704NIGMS NIH HHS R01 GM063904NIGMS NIH HHS R56 GM063904NIH HHS OT2 OD026580NIH HHS R24 OD036201NIH HHS R44 OD024874
Abstract
Previously we showed the generation of a protein trap library made with the gene-break transposon (GBT) in zebrafish (
Indexed as
Sick Sinus SyndromeZebrafishAnimalsArrhythmias, CardiacElectrocardiographyHSP40 Heat-Shock ProteinsHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMiceMolecular ChaperonesNerve Tissue ProteinsPhenotypeSinoatrial NodeDNAJB6 protein, humanHSP40 Heat-Shock ProteinsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMolecular ChaperonesNerve Tissue ProteinsDnajb6electrocardiogramgenetic diseasesgeneticsgenomicssick sinus syndromesinus arrestzebrafish
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.