Evidence map›Paper›PMID 36255052›Full record

ArticleeLife2022

Inhibited KdpFABC transitions into an E1 off-cycle state.

Jakob M Silberberg, Charlott Stock, Lisa Hielkema, Robin A Corey, Jan Rheinberger, Dorith Wunnicke, Victor R A Dubach, Phillip J Stansfeld, Inga Hänelt, Cristina Paulino

Abstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Lipids are essential for potassium transport by KdpFABC from E. coli.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Conduction pathway for potassium through the E. coli pump KdpFABC.bioRxiv : the preprint server for biology · 2025
    Article
  4. P-type ATPase magnesium transporter MgtA acts as a dimer.Nature structural & molecular biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Automated model-free analysis of cryo-EM volume ensembles with SIREn.bioRxiv : the preprint server for biology · 2024
    Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jakob M Silberberg *Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt, Germany.ORCID 0000-0003-1721-8666
Charlott Stock *Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt, Germany.ORCID 0000-0001-5471-3696
Lisa Hielkema *Department of Structural Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, Netherlands.
Robin A CoreyDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-1820-7993
Jan RheinbergerDepartment of Structural Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, Netherlands.ORCID 0000-0002-9901-2065
Dorith WunnickeInstitute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt, Germany.
Victor R A DubachDepartment of Structural Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, Netherlands.ORCID 0000-0002-1657-7184
Phillip J StansfeldSchool of Life Sciences & Department of Chemistry, University of Warwick, Coventry, United Kingdom.
Inga HäneltInstitute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt, Germany.ORCID 0000-0003-1495-3163
Cristina PaulinoDepartment of Structural Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, Netherlands.ORCID 0000-0001-7017-109X

Funding

Biotechnology and Biological Sciences Research Council BB/P01948X/1Biotechnology and Biological Sciences Research Council BB/R002517/1Biotechnology and Biological Sciences Research Council BB/S003339/1Medical Research Council MR/S009213/1Wellcome TrustWellcome Trust 208361/Z/17/Z
6 · The paper itself

Abstract

KdpFABC is a high-affinity prokaryotic K

Indexed as

Cation Transport ProteinsEscherichia coli ProteinsP-type ATPasesEscherichia coliPotassiumCation Transport ProteinsEscherichia coli ProteinsPotassiumP-type ATPasescryo-EME. colimembrane transport mechanismmolecular biophysicspotassium uptakeprotein regulationP-type ATPasestructural biologystructure–function

Identifiers

PMID36255052
PMCPMC9651954

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.