Evidence map›Paper›PMID 36255051›Full record

ArticleeLife2022

Delineating the transcriptional landscape and clonal diversity of virus-specific CD4

Ryan Zander, Achia Khatun, Moujtaba Y Kasmani, Yao Chen, Weiguo Cui

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A new 'K'ind of T helper cell.Nature immunology · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Advances in Single-Cell Sequencing for Infectious Diseases: Progress and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. CD8Cellular & molecular immunology · 2023
    Article
  20. Cytotoxic CD4Frontiers in immunology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ryan Zander *Blood Research Institute, Versiti Wisconsin, Milwaukee, United States.ORCID 0000-0002-7431-8535
Achia Khatun *Blood Research Institute, Versiti Wisconsin, Milwaukee, United States.
Moujtaba Y KasmaniBlood Research Institute, Versiti Wisconsin, Milwaukee, United States.ORCID 0000-0002-5753-5335
Yao ChenBlood Research Institute, Versiti Wisconsin, Milwaukee, United States.
Weiguo CuiBlood Research Institute, Versiti Wisconsin, Milwaukee, United States.ORCID 0000-0003-1562-9218
Medical College of Wisconsin · USVersiti Blood Center of Wisconsin · US

Funding

Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
Phenotypic, Functional and Transcriptional Heterogeneity in T Cell ExhaustionR01AI148403 · NIAID · VERSITI WISCONSIN, INC. · PI WEIGUO CUI · 2020 to 2026
$3.1M
The Cellular and Transcriptional Control of CD8 T Cell Functional Adaptation to Chronic VirusesR01AI125741 · NIAID · VERSITI WISCONSIN, INC. · PI CUI, WEIGUO · 2016 to 2020
$2.1M
Defining the transcriptional, phenotypic, and functional heterogeneity of virus-specific CD4 T cells during chronic viral infectionR00AI153537 · NIAID · UNIVERSITY OF IOWA · PI ZANDER, RYAN · 2022 to 2023
$498k
Defining the transcriptional, phenotypic, and functional heterogeneity of virus-specific CD4 T cells during chronic viral infectionK99AI153537 · NIAID · VERSITI WISCONSIN, INC. · PI ZANDER, RYAN · 2020 to 2021
$224k
Mechanistic study of TCR signaling strength in CD8 T cell differentiation during pathogenesis of T1DMF30DK127526 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI KASMANI, MOUJTABA Y · 2020 to 2023
$198k
NIAID NIH HHS K99 AI153537NIAID NIH HHS R00 AI153537NIAID NIH HHS R01 AI125741NIAID NIH HHS R01 AI148403NIDDK NIH HHS F30 DK127526NIGMS NIH HHS T32 GM080202
6 · The paper itself

Abstract

Although recent evidence indicates that CD4

Indexed as

Graft vs Host DiseaseLymphocytic ChoriomeningitisAnimalsCD4-Positive T-LymphocytesLymphocytic choriomeningitis virusMiceMice, Inbred C57BLReceptors, Antigen, T-CellT-Lymphocyte SubsetsReceptors, Antigen, T-CellCD4+ T cell differentiationchronic viral infectioncomputational biologyimmunologyinflammationmousescRNAseqsystems biology

Identifiers

PMID36255051
PMCPMC9629829
OpenAlexW4306698314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.