Evidence map›Paper›PMID 36254928›Full record

ReviewSingapore medical journal2024

Antenatal corticosteroids in Singapore: a clinical and scientific assessment.

Arundhati Gosavi, Zubair Amin, Sean William David Carter, Mahesh Arjandas Choolani, Erin Lesley Fee, Mark Amir Milad, Alan Hall Jobe, Matthew Warren Kemp

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Singapore medical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06974188 (AI-Powered CURAᵀᴹ Application for Identifying At-Risk Pregnancies in Obstetric Management), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06974188 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

AI-Powered CURAᵀᴹ Application for Identifying At-Risk Pregnancies in Obstetric Management: A Randomized Controlled Trial (CURAte)

TypeinterventionalSponsorNational University Hospital, SingaporeRan2025 to 2027Enrolled1,700ConditionsHigh-risk Pregnancy, Pregnancy, Antenatal HealthArmsAI-risk Stratification
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Arundhati GosaviDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Zubair AminDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Sean William David CarterDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia.
Mahesh Arjandas ChoolaniDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Erin Lesley FeeDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia.
Mark Amir MiladMilad Pharmaceutical Consulting LLC, Plymouth, Michigan, USA.
Alan Hall JobePerinatal Research, Department of Pediatrics, Cincinnati Children's Hospital Medical Centre, University of Cincinnati, Cincinnati, Ohio, USA.
Matthew Warren KempDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
National University of Singapore · SGUniversity of Western Australia · AUCincinnati Children's Hospital Medical Center · USTohoku University Hospital · JPUniversity of Cincinnati · USWeatherford College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractPreterm birth (PTB; delivery prior to 37 weeks' gestation) is the leading cause of early childhood death in Singapore today. Approximately 9% of Singaporean babies are born preterm; the PTB rate is likely to increase given the increased use of assisted reproduction technologies, changes in the incidence of gestational diabetes/high body mass index and the ageing maternal population. Antenatal administration of dexamethasone phosphate is a key component of the obstetric management of Singaporean women who are at risk of imminent preterm labour. Dexamethasone improves preterm outcomes by crossing the placenta to functionally mature the fetal lung. The dexamethasone regimen used in Singapore today affords a very high maternofetal drug exposure over a brief period of time. Drawing on clinical and experimental data, we reviewed the pharmacokinetic profile and pharmacodynamic effects of dexamethasone treatment regimen in Singapore, with a view to creating a development pipeline for optimising this critically important antenatal therapy.

Indexed as

DexamethasonePremature BirthAdrenal Cortex HormonesFemaleHumansInfant, NewbornObstetric Labor, PrematurePregnancyPrenatal CareSingaporeAdrenal Cortex HormonesDexamethasone

Identifiers

PMID36254928
PMCPMC11479002
OpenAlexW4306734402

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.