ArticleJournal of veterinary internal medicine2022
Retrospective evaluation of risk factors for development of kidney injury after parenteral furosemide treatment of left-sided congestive heart failure in dogs.
Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Prognostic relevance of short-term changes in body weight, renal indices, and echocardiographic variables after intravenous diuretic therapy in dogs with myxomatous mitral valve disease hospitalized for pulmonary edema.The veterinary quarterly · 2026Article
- Evaluation of Urinary Tubular Biomarkers in Dogs with Myxomatous Mitral Valve Disease Across ACVIM Stages.Veterinary sciences · 2026Article
- Incidence, risk factors, and prognosis of acute kidney injury in mechanically ventilated dogs and cats.Frontiers in veterinary science · 2026Article
- Dogs and cats with acute-on-chronic kidney disease have worse outcomes than those with acute kidney injury following renal replacement therapy.Frontiers in veterinary science · 2026Article
- Article
- Clinical findings and risk factors for clinical outcomes in dogs with myxomatous mitral valve disease hospitalized for cardiogenic pulmonary edema.Frontiers in veterinary science · 2026Article
- Sodium-glucose co-transporter 2 inhibitors: Prospects for canine myxomatous mitral valve disease and finding the "right drug" and the "right dose" for dogs.The Journal of veterinary medical science · 2025Review
- Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a Biomarker of Acute Kidney Injury (AKI) in Dogs with Congestive Heart Failure (CHF) Due to Myxomatous Mitral Valve Disease (MMVD).Animals : an open access journal from MDPI · 2025Article
- Retrospective evaluation of risk factors for development of kidney injury after parenteral furosemide treatment of left-sided congestive heart failure in dogs.Journal of veterinary internal medicine · 2022Article
- Retrospective evaluation of risk factors for worsening renal function after angiotensin-converting enzyme inhibitor treatment in dogs.Journal of veterinary internal medicineArticle
- Frequency and progression of azotemia during acute and chronic treatment of congestive heart failure in cats.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKidney injury (KI) has been documented in dogs treated with furosemide for left-sided congestive heart failure (CHF). HYPOTHESIS/
objectivesDetermine risk factors for development of KI in furosemide-treated dogs and determine the effect of KI on survival. ANIMALS: Seventy-nine client-owned dogs receiving parenteral furosemide for CHF.
methodsSerum creatinine (sCr) and electrolyte concentrations were determined during hospitalization and at first outpatient reevaluation to detect and stage KI (increase in sCr ≥0.3 mg/dL). Furosemide dosage administered between timepoints was calculated. Multivariable modeling was performed to identify predictors of KI and percent change in serum biochemistry results over time.
resultsKidney injury was identified in 38/79 (48%) dogs and mostly occurred during hospitalization. Kidney injury was Grade I in 25 dogs, Grade II in 9 dogs, and Grade III in 4 dogs. Higher blood pressure was associated with acute KI during hospitalization (odds ratio, 1.03; 95% confidence interval [95% CI] 1.01-1.07; P = .03) whereas PO furosemide dosage was associated with KI after hospital discharge (odds ratio, 7.77; 95% CI, 2.05-68.6; P = .02). Baseline sCr and use of a furosemide continuous rate infusion were not associated with increased risk of KI. Kidney injury was not associated with long-term outcome. Of 13 dogs with Grade II-III KI, azotemia was reversible in 9 dogs, and 6 dogs survived >1 year after KI. CONCLUSIONS AND CLINICAL IMPORTANCE: In this cohort of dogs receiving parenteral furosemide for CHF, KI was common, mostly nonazotemic (Grade I), and did not impact survival.
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