Evidence map›Paper›PMID 36254522›Full record

ReviewTransplant infectious disease : an official journal of the Transplantation Society2022

Beta-lactam allergies, surgical site infections, and prophylaxis in solid organ transplant recipients at a single center: A retrospective cohort study.

Clayton Mowrer, Elizabeth Lyden, Stephen Matthews, Anum Abbas, Scott Bergman, Bryan T Alexander, Trevor C Van Schooneveld, Erica J Stohs

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Transplant infectious disease : an official journal of the Transplantation Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Clayton MowrerDivision of Infectious Diseases, Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Elizabeth LydenDepartment of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Stephen MatthewsInfection Control and Epidemiology, Nebraska Medicine, Omaha, Nebraska, USA.
Anum AbbasDivision of Infectious Diseases, Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0001-5891-2019
Scott BergmanDepartment of Pharmaceutical and Nutritional Care, Nebraska Medicine, Omaha, Nebraska, USA.
Bryan T AlexanderDepartment of Pharmaceutical and Nutritional Care, Nebraska Medicine, Omaha, Nebraska, USA.
Trevor C Van SchooneveldDivision of Infectious Diseases, Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Erica J StohsDivision of Infectious Diseases, Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0002-8324-6414
University of Nebraska Medical Center · USNebraska Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBeta-lactam allergies (BLAs) are common in hospitalized patients, including transplant recipients. BLA is associated with decreased use of preferred surgical site infection (SSI) prophylaxis and increased SSIs, but this has not been studied in the transplant population.

methodsWe reviewed adult heart, kidney, and liver transplant recipients between January 1, 2016 and December 31, 2019 to characterize reported BLA and collect SSI prophylaxis regimens at time of transplant. We compared the use of preferred SSI prophylaxis and SSI incidence based on reported BLA status. Post hoc we collected antibiotic days of therapy (DOT) (excluding pneumocystis prophylaxis) in the 30-day period posttransplant for patients without SSI. We utilized descriptive statistics for comparisons.

resultsOf 691 patients included (116 heart, 400 kidney, and 175 liver transplant recipients), 118 (17%) reported BLA. Rash and hives were the two most reported BLA reactions (36% and 24%), categorized as potential T-cell mediated and IgE mediated, respectively. Preferred SSI prophylaxis was prescribed in 13 (11%) patients with BLA and 573 (92%) without BLA (p < .001). No difference could be detected in SSI incidence between BLA and non-BLA patients (4.2 vs. 4.3%, p = 1.0). Of 659 without SSI, 169 (25.6%) received antibiotics within 30 days of transplant; mean antibiotic DOT for BLA and non-BLA patients were 3.5 ± 8.0 versus 2.3 ± 5.8, p = .12.

conclusionBLA transplant recipients received nonpreferred SSI prophylaxis more frequently than non-BLA recipients, but there was no difference in 30-day SSIs between the groups. One-fourth of solid organ transplant recipients received systemic antibiotics within 30 days of transplant.

Indexed as

HypersensitivityOrgan TransplantationAdultAnti-Bacterial AgentsAntibiotic Prophylaxisbeta-LactamsHumansImmunoglobulin ERetrospective StudiesSurgical Wound InfectionTransplant RecipientsAnti-Bacterial Agentsbeta-LactamsImmunoglobulin Eantibiotic allergysolid organ transplantsurgical site infection prophylaxissurgical site infections

Identifiers

PMID36254522
PMCPMC9787036
OpenAlexW4306682773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.