Evidence map›Paper›PMID 36254439›Full record

ArticleArquivos de neuro-psiquiatria2022

Misdiagnoses in a Brazilian population with amyotrophic lateral sclerosis.

Vinicius Stefani Borghetti, Vívian Pedigone Cintra, Jean de Oliveira Ramos, Vanessa Daccach Marques, Patrícia Toscano Onofre, Victor Augusto Souza Santana, Lua Flora Pereira Bezerra, Pedro José Tomaselli, André Cleriston José Dos Santos, Claudia Ferreira da Rosa Sobreira and 1 more

Open access · goldAbstract read
In one paragraph

Article in Arquivos de neuro-psiquiatria, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Vinicius Stefani BorghettiUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto SP, Brazil.ORCID 0000-0001-6786-9868
Vívian Pedigone CintraUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto SP, Brazil.ORCID 0000-0002-4908-9320
Jean de Oliveira RamosUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto SP, Brazil.ORCID 0000-0002-6648-3450
Vanessa Daccach MarquesUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto SP, Brazil.ORCID 0000-0002-2131-9438
Patrícia Toscano OnofreUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto SP, Brazil.ORCID 0000-0002-3832-2131
Victor Augusto Souza SantanaCentro Universitário Municipal de Franca, Franca SP, Brazil.ORCID 0000-0003-2217-9497
Lua Flora Pereira BezerraCentro Universitário Municipal de Franca, Franca SP, Brazil.ORCID 0000-0002-0424-6126
Pedro José TomaselliUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto SP, Brazil.ORCID 0000-0002-1485-3771
André Cleriston José Dos SantosUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto SP, Brazil.ORCID 0000-0003-2919-565X
Claudia Ferreira da Rosa SobreiraUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto SP, Brazil.ORCID 0000-0002-7420-1644
Wilson MarquesUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto SP, Brazil.ORCID 0000-0002-4589-2749
Universidade de Ribeirão Preto · BRCentro Universitário de Franca · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects the upper and lower motor neurons. The correct diagnosis at the onset of the disease is sometimes very difficult, due to the symptoms being very similar to those of other neurological syndromes.

objectiveThis study aimed to analyze the initial manifestations, the specialty of the first physician visited due the initial complaint, the misdiagnoses, as well as the unnecessary surgical interventions in a new ALS Brazilian population.

methodsThe medical records of 173 patients with typical ALS were reviewed.

resultsThe present study demonstrated that other symptoms, besides weakness, were very frequent as initial presentation of ALS, and orthopedics was the medical specialty most sought by patients at the onset of symptoms. Our frequency of misdiagnoses was 69.7%, and in 7.1% of them, an unnecessary surgical intervention was performed.

conclusionsAmyotrophic lateral sclerosis presents a very large pool of signs and symptoms; therefore, there is an urgent need of increasing the disease awareness to other specialties due to the high frequency of misdiagnoses observed in clinical practice.

Indexed as

Amyotrophic Lateral SclerosisNeurodegenerative DiseasesBrazilDiagnostic ErrorsHumansMotor Neurons

Identifiers

PMID36254439
PMCPMC9685820
OpenAlexW4306729515

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.