Evidence map›Paper›PMID 36254171›Full record

ArticleeNeurologicalSci2022

Objective perimetry and progression of multiple sclerosis.

Ted Maddess, Corinne F Carle, Emilie M F Rohan, Jonathan Baird-Gunning, Josh P van Kleef, Christian J Lueck

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeurologicalSci, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ted MaddessEccles Institute of Neuroscience, John Curtin School of Medical Research, Australian National University, Acton, ACT, Australia.
Corinne F CarleEccles Institute of Neuroscience, John Curtin School of Medical Research, Australian National University, Acton, ACT, Australia.
Emilie M F RohanEccles Institute of Neuroscience, John Curtin School of Medical Research, Australian National University, Acton, ACT, Australia.
Jonathan Baird-GunningRoyal North Shore Hospital, Saint Leonards, New South Wales, Australia.
Josh P van KleefEccles Institute of Neuroscience, John Curtin School of Medical Research, Australian National University, Acton, ACT, Australia.
Christian J LueckDepartment of Neurology, the Canberra Hospital, Canberra, ACT, Australia.
Australian National University · AUCanberra Hospital · AURoyal North Shore Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: We re-examined the per-region response amplitudes and delays obtained from multifocal pupillographic objective perimetry (mfPOP) after 10 years in 44 persons living with multiple sclerosis (PwMS), both to examine which parts of the visual field had progressed in terms of response properties and to examine if the baseline data could predict the overall progression of disease. Methods: Expanded Disability Status Scale (EDSS) scores were assessed in 2009 and 2019. Both eyes of each participant were concurrently tested at 44 locations/eye on both occasions. Several measures of clinical progression were examined, using logistic regression to determine the odds of progression. Results: At the second examination the 44 PwMS (31 females) were aged 61.0 ± 12.2 y. Mean EDSS had not changed significantly (3.69 ± 1.23 in 2009, 3.81 ± 2.00 in 2019). mfPOP delay increased progressively from inferior to superior regions of the visual fields while amplitudes demonstrated a temporal to nasal gradient. The mean of the 3 most delayed visual field regions was correlated with progression of MS by 2019 ( Significance: mfPOP may provide a rapid, convenient method of monitoring and predicting MS progression.

Indexed as

Disability progressionMultiple sclerosisObjective perimetryPupillary response

Identifiers

PMID36254171
PMCPMC9568864
OpenAlexW4303627995

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.