ArticlePediatric obesity2023
Longitudinal assessment of brain structure and behaviour in youth with rapid weight gain: Potential contributing causes and consequences.
Article in Pediatric obesity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Weight gain and brain development in the ABCD study cohort: A decade of insight and the road ahead.Developmental cognitive neuroscience · 2026Review
- Cardiometabolic Risk and Structural Brain Development in a Large Community-Based US Cohort.Human brain mapping · 2026Article
- Cardiometabolic risk and structural brain development in a large community-based U.S. cohort.medRxiv : the preprint server for health sciences · 2025Article
- Appetite Self-Regulation in Childhood: A Narrative Review and Conceptual Model of Processes and Mechanisms With Implications for Research and Practice.Nutrition reviews · 2025Review
- Longitudinal Sex-at-Birth and Age Analyses of Cortical Structure in the ABCD Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Smaller subcortical volume relates to greater weight gain in girls with initially healthy weight.Obesity (Silver Spring, Md.) · 2024Article
- Limitations of BMI z scores for assessing weight change: A clinical tool versus individual risk.Obesity (Silver Spring, Md.) · 2024Article
- Variation in executive function relates to BMI increases in youth who were initially of a healthy weight in the ABCD Study.Obesity (Silver Spring, Md.) · 2023Article
- Is there a role for higher cognitive processes in the development of obesity in humans?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Loss of control eating in children is associated with altered cortical and subcortical brain structure.Frontiers in psychology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveIndependent of weight status, rapid weight gain has been associated with underlying brain structure variation in regions associated with food intake and impulsivity among pre-adolescents. Yet, we lack clarity on how developmental maturation coincides with rapid weight gain and weight stability.
methodsWe identified brain predictors of 2-year rapid weight gain and its longitudinal effects on brain structure and impulsivity in the Adolescent Brain Cognitive Development
resultsA fivefold cross-validated logistic elastic-net regression revealed that rapid weight gain was associated with structural variation amongst 39 brain features at 9-to-10-years-old in regions involved with executive functioning, appetitive control and reward sensitivity. Two years later, WG youth showed differences in change over time in several of these regions and performed worse on measures of impulsivity.
conclusionsThese findings suggest that brain structure in pre-adolescence may predispose some to rapid weight gain and that weight gain itself may alter maturational brain change in regions important for food intake and impulsivity. Behavioural interventions that target inhibitory control may improve trajectories of brain maturation and facilitate healthier behaviours.
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