Evidence map›Paper›PMID 36253732›Full record

Trial reportThe journal of headache and pain2022

CGRP-induced migraine-like headache in persistent post-traumatic headache attributed to mild traumatic brain injury.

Håkan Ashina, Afrim Iljazi, Haidar M Al-Khazali, Thien Phu Do, Anna K Eigenbrodt, Eigil L Larsen, Amalie M Andersen, Kevin J Hansen, Karoline B Bräuner, Basit Ali Chaudhry and 3 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of headache and pain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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  11. Biomarkers and Endophenotypes of Post-traumatic Headaches.Current pain and headache reports · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Håkan AshinaDepartment of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Afrim IljaziDanish Headache Center, Department of Neurology, Faculty of Health and Medical Sciences, Rigshospitalet - Glostrup, University of Copenhagen, Copenhagen, Denmark.
Haidar M Al-KhazaliDanish Headache Center, Department of Neurology, Faculty of Health and Medical Sciences, Rigshospitalet - Glostrup, University of Copenhagen, Copenhagen, Denmark.
Thien Phu DoDanish Headache Center, Department of Neurology, Faculty of Health and Medical Sciences, Rigshospitalet - Glostrup, University of Copenhagen, Copenhagen, Denmark.
Anna K EigenbrodtDanish Headache Center, Department of Neurology, Faculty of Health and Medical Sciences, Rigshospitalet - Glostrup, University of Copenhagen, Copenhagen, Denmark.
Eigil L LarsenDanish Headache Center, Department of Neurology, Faculty of Health and Medical Sciences, Rigshospitalet - Glostrup, University of Copenhagen, Copenhagen, Denmark.
Amalie M AndersenDanish Headache Center, Department of Neurology, Faculty of Health and Medical Sciences, Rigshospitalet - Glostrup, University of Copenhagen, Copenhagen, Denmark.
Kevin J HansenDanish Headache Center, Department of Neurology, Faculty of Health and Medical Sciences, Rigshospitalet - Glostrup, University of Copenhagen, Copenhagen, Denmark.
Karoline B BräunerDanish Headache Center, Department of Neurology, Faculty of Health and Medical Sciences, Rigshospitalet - Glostrup, University of Copenhagen, Copenhagen, Denmark.
Basit Ali ChaudhryDanish Headache Center, Department of Neurology, Faculty of Health and Medical Sciences, Rigshospitalet - Glostrup, University of Copenhagen, Copenhagen, Denmark.
Casper E ChristensenDanish Headache Center, Department of Neurology, Faculty of Health and Medical Sciences, Rigshospitalet - Glostrup, University of Copenhagen, Copenhagen, Denmark.
Faisal Mohammad AminDanish Headache Center, Department of Neurology, Faculty of Health and Medical Sciences, Rigshospitalet - Glostrup, University of Copenhagen, Copenhagen, Denmark.
Henrik W SchytzDanish Headache Center, Department of Neurology, Faculty of Health and Medical Sciences, Rigshospitalet - Glostrup, University of Copenhagen, Copenhagen, Denmark. henrik.winther.schytz.01@regionh.dk.
Rigshospitalet · DKUniversity of Copenhagen · DKHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo ascertain whether intravenous infusion of calcitonin gene-related peptide (CGRP) can induce migraine-like headache in people with persistent post-traumatic headache attributed to mild traumatic brain injury (TBI) and no pre-existing migraine.

methodsA non-randomized, single-arm, open-label study at a single site in Denmark. Eligible participants were aged 18 to 65 years and had a known history of persistent post-traumatic headache attributed to mild TBI for ≥ 12 months. All participants received continuous intravenous infusion of CGRP (1.5 µg/min) over 20 min. A headache diary was used to collect outcome data until 12 h after the start of CGRP infusion. The primary end point was the incidence of migraine-like headache during 12-hour observational period.

resultsA total of 60 participants completed the study protocol and provided data for the analysis of the primary end point. The median age was 32.5 (IQR, 25.5-43.0) years; 43 participants (72%) were female. Following CGRP infusion, 43 (72%) of 60 participants developed migraine-like headache during the 12-hour observational period. The median time to peak headache intensity was 40 min (IQR, 20-60), and the median peak headache intensity was 6 (IQR, 5-8) on the 11-point numeric rating scale.

conclusionIntravenous infusion of CGRP is a potent inducer of migraine-like headache in people with persistent post-traumatic headache attributed to mild TBI. This observation underscores the importance of CGRP in the genesis of migraine-like headache that is often experienced by individuals who are afflicted by persistent post-traumatic headache. Further research is warranted to ascertain whether other signaling molecules also contribute to the disease mechanisms underlying post-traumatic headache.

Indexed as

Brain ConcussionMigraine DisordersPost-Traumatic HeadacheTension-Type HeadacheAdultCalcitonin Gene-Related PeptideFemaleHeadacheHumansMaleCalcitonin Gene-Related PeptideCGRPConcussionMigrainePathophysiologyTrigeminovascular System

Identifiers

PMID36253732
PMCPMC9578273
OpenAlexW4306406741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.