ArticleBMC geriatrics2022
Self-perceived burden predicts lower quality of life in advanced cancer patients: the mediating role of existential distress and anxiety.
Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 29 citations in OpenAlex.
- Investigation of Machine Learning Models for Anxiety Levels Assessment in Patients With Breast Cancer Using Self-Questionnaires.Journal of Korean medical science · 2026Article
- Article
- Self-esteem and existential distress among patients with advanced cancer: mediation by a sense of control and meaning in life.Frontiers in psychology · 2026Article
- Psychological distress and its associated factors among cancer patients in Nepal: A cross-sectional study.PLOS mental health · 2026Article
- Effect of symptom clusters on quality of life in patients with head and neck cancer treated with radiotherapy: a cross-sectional study.Scientific reports · 2025Article
- Initial quality of life and influencing factors in patients with advanced cancer receiving home hospice care: A propensity score-matched analysis stratified by survival period.Asia-Pacific journal of oncology nursing · 2025Article
- Relationship between psychological resilience and quality of life in cancer patients and the multiple mediating roles of stigma and self perceived burden.Scientific reports · 2025Article
- Social alienation and related factors in patients with head and neck tumors undergoing radiotherapy: a cross-sectional study.BMC nursing · 2025Article
- Compounding strain: The impact of caregiver strain on health outcomes in older adults with new cancer diagnoses.Journal of geriatric oncology · 2025Article
- Nutrition Security During Cancer: A Qualitative Investigation Among Patients With Cancer on Active Treatment From an Area of Persistent Poverty.Cancer reports (Hoboken, N.J.) · 2025Article
- Family Function and Self-Management of Patients With Early Chronic Kidney Disease: The Mediating Roles of Self-Perceived Burden and Ego Depletion.Patient preference and adherence · 2025Article
- The Impact of Self-Perceived Burden on Loneliness in Stroke Patients: The Mediating Role of Rumination.Patient related outcome measures · 2025Article
- Number of palliative care nurse home visits and duration of palliative care associated with domains of the Good Death Inventory: A national survey of bereaved family caregivers in a middle income country.International journal of nursing studies advances · 2024Article
- Understanding caregiver burden from multiple perspectives: dyadic agreement between caregiver and care recipient.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Mediating the Role of Perceived Social Support Between Frailty and Self-Perceived Burden in Elderly Patients with Diabetes.Patient preference and adherence · 2024Article
- Influence of Financial Toxicity on the Quality of Life in Lung Cancer Patients Undergoing Immunotherapy: The Mediating Effect of Self-Perceived Burden.Cancer management and research · 2024Article
- Article
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSelf-perceived burden (SPB) is an important predictor of quality of life (QoL) in patients with advanced cancer. However, the mechanism how SPB affects patients' QoL remains unclear. This study aimed to examine the potential mediating roles of existential distress (ED) and anxiety in the relationship between SPB and QoL.
methodsA multicenter cross-sectional study was conducted. 352 advanced cancer patients were recruited from three hospitals in southeast of China. The Self-perceived Burden Scale, the Existential Distress Scale, the Hospital Anxiety and Depression Scale, and the Quality-of-Life Concerns in the End of Life Questionnaire were adopted to collect data. Hayes's bootstrapping method was used to analyze the data.
resultsSPB was negatively associated with QoL (P < 0.01). ED and anxiety partially mediated the relationship between SPB and QoL (P < 0.01). Moreover, ED had direct effects on anxiety, and sequentially QoL (P < 0.01). The serial multiple mediation model of SPB accounted for 73.25% of the variance in QoL in advanced cancer patients.
conclusionsED and anxiety are important mediating factors between SPB and QoL in advanced cancer patients. To improve patients' QoL, comprehensive interventions for reducing anxiety and ED are highly recommended in clinical practices.
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