Evidence map›Paper›PMID 36253662›Full record

ArticleInternational journal of clinical pharmacy2023

Sex differences among users of NSAIDs and opioids during COVID-19 Pandemic.

Roseanne Offiah, Laila Aboulatta, Payam Peymani, Basma Aloud, Kaarina Kowalec, Christine Leong, Joseph Delaney, Jamie Falk, Silvia Alessi-Severini, Sherif Eltonsy

Open access · bronzeAbstract read
In one paragraph

Article in International journal of clinical pharmacy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Roseanne OffiahUniversity of Exeter Medical School, Exeter, UK.
Laila AboulattaRady Faculty of Health Sciences, College of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada.
Payam PeymaniRady Faculty of Health Sciences, College of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada.
Basma AloudRady Faculty of Health Sciences, College of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada.
Kaarina KowalecRady Faculty of Health Sciences, College of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada.
Christine LeongRady Faculty of Health Sciences, College of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada.
Joseph DelaneyRady Faculty of Health Sciences, College of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada.
Jamie FalkRady Faculty of Health Sciences, College of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada.
Silvia Alessi-SeveriniRady Faculty of Health Sciences, College of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada.
Sherif EltonsyRady Faculty of Health Sciences, College of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada. Sherif.Eltonsy@umanitoba.ca.ORCID http://orcid.org/0000-0002-0520-5406
University of Manitoba · CAChildren's Hospital Research Institute of Manitoba · CAKarolinska Institutet · SEManitoba Health · CAUniversity of Exeter · GBUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSex-based inequalities in healthcare have been exposed and amplified during the COVID-19 pandemic. However, few studies have reported sex differences in medication utilization and no studies have examined sex differences in prescribed non-steroidal anti-inflammatory drugs (NSAIDs) and opioids utilization.

aimTo compare the utilization patterns of prescribed NSAIDs and opioids between males and females in Manitoba, Canada during the COVID-19 pandemic.

methodA cohort of incident and prevalent users of prescribed NSAIDs and opioids was created. Interrupted times series analysis using autoregressive models were used to evaluate the quarterly change in the prevalent and incident users before and after COVID-19 restrictions were applied (first quarter of 2020).

resultsCOVID-19 restrictions were associated with a significant decrease in the utilization of prescribed NSAIDs and opioids in all users, followed by a revert to the pre-pandemic trends. Among female prevalent and incident NSAIDs users, there was a significant change in trend after COVID-19 restrictions were introduced (β

conclusionIn this study, a significant sharp decline in the use of prescribed NSAIDs and opioids was shown in both sexes at the onset of the pandemic. However, a significant upward trend is observed in female NSAIDs users as restrictions began to be lifted.

Indexed as

Analgesics, OpioidCOVID-19Anti-Inflammatory Agents, Non-SteroidalFemaleHumansMalePandemicsSex CharacteristicsAnalgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalCOVID-19 pandemicNSIADsOpioidsSex differenceUtilization

Identifiers

PMID36253662
PMCPMC9575648
OpenAlexW4306411972

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.