Evidence map›Paper›PMID 36253639›Full record

ArticleVeterinary medicine and science2023

Evaluation of therapeutic effects of an herbal mixture (Echinacea purpurea and Glycyrrhiza glabra) for treatment of clinical coccidiosis in broilers.

Seyed Ali Ghafouri, Abolfazl Ghaniei, Amir Ebrahim Tavanaee Tamannaei, Soheil Sadr, Ali Charbgoo, Shakila Ghiassi, Morteza Abuali

Open access · goldAbstract read
In one paragraph

Article in Veterinary medicine and science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Parasites of poultry in Nigeria from 1980 to 2022: a review.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025
    Review
  4. Article
  5. Frontiers in immunology · 2025
    Article
  6. Growth performance and immune response of broilers during activeAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2024
    Article
  7. Echinacea: Bioactive Compounds and Agronomy.Plants (Basel, Switzerland) · 2024
    Review
  8. Article
  9. Article
  10. Efficacy of dietary supplements ofOpen veterinary journal · 2024
    Article
  11. Article
  12. Anticoccidial effects of tannin-based herbal formulation (Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023
    Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Seyed Ali GhafouriDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Abolfazl GhanieiDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.ORCID 0000-0003-0341-6987
Amir Ebrahim Tavanaee TamannaeiDepartment of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Soheil SadrDepartment of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.ORCID 0000-0002-9068-0673
Ali CharbgooDepartment of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Shakila GhiassiDepartment of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Morteza AbualiMedicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.
Ferdowsi University of Mashhad · IRAcademic Center for Education, Culture and Research · IR

Funding

Wellcome Trust 102181
6 · The paper itself

Abstract

backgroundAvian coccidiosis is thought to be one of the most expensive infectious diseases in the poultry industry.

objectivesSafe and alternative anti-coccidial drugs are herbal extracts because they do not result in tissue residue and drug resistance. The objective of the present study was to evaluate the anti-coccidial effect of the herbal mixture, a complex of two plants (Echinacea purpurea, Glycyrrhiza glabra) in broiler chickens in comparison with toltrazuril.

methodsOne hundred twenty broiler chickens were used in this experiment and divided into 4 equally numbered groups. All the groups, except Group D, were experimentally infected with mixed Eimeria spp. (E. Tenella, E. maxima, E. necatrix and E. brunetti) on day 14. Group A treated with an herbal mixture [Glycyrrhiza glabra Extract 5% (standardised to 5.4% glycyrrhizic acid) and Echinacea purpurea Extract 2% (standardised to 4% total phenolic content based on chlorogenic acid); Coxinin-EC

resultsPositive control group had the poorest results and more mortality than other groups. Group D was not infected and was healthy all the experiment period. Treatment with herbal complex significantly reduced the negative performance and pathogenic effects associated with Eimeria spp. at a level that was comparable with toltrazuril.

conclusionsIn summary, the anti-coccidial activity of the studied herbal complex suggests its use as an alternative anti-coccidial agent to chemotherapeutic drugs for controlling coccidiosis in poultry. HIGHLIGHTS: -Coccidiosis is an important infectious disease that causes serious financial loss to the poultry industry. -Chemical anti-coccidial drugs and vaccines are the main control strategies to combat the disease. However, these tools have some constraints. -Herbal remedies are suitable alternatives to chemical compounds for control of losses associated with coccidiosis in poultry. -An herbal mixture (Echinacea purpurea, Glycyrrhiza glabra) has promising effects for controlling of coccidiosis in broiler chickens.

Indexed as

CoccidiosisEchinaceaEimeriaGlycyrrhizaPoultry DiseasesAnimalsChickensPlant ExtractsEchinacea extractGlycyrrhiza glabra extractPlant Extractschickencoccidiosis controlherbal medicine

Identifiers

PMID36253639
PMCPMC10029886
OpenAlexW4306658495

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.