Evidence map›Paper›PMID 36253513›Full record

ArticleNature microbiology2022

Retrospective detection of monkeypox virus in the testes of nonhuman primate survivors.

Jun Liu, Eric M Mucker, Jennifer L Chapman, April M Babka, Jamal M Gordon, Ashley V Bryan, Jo Lynne W Raymond, Todd M Bell, Paul R Facemire, Arthur J Goff and 2 more

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Nature microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 37 citations in OpenAlex.

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  14. A comprehensive review of monkeypox virus and mpox characteristics.Frontiers in cellular and infection microbiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jun LiuUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
Eric M MuckerUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
Jennifer L ChapmanUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
April M BabkaUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
Jamal M GordonUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
Ashley V BryanUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
Jo Lynne W RaymondUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
Todd M BellUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
Paul R FacemireUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
Arthur J GoffUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
Aysegul NalcaUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
Xiankun ZengUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA. xiankun.zeng.civ@health.mil.ORCID http://orcid.org/0000-0003-3526-8755
United States Army Medical Research Institute of Infectious Diseases · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Close contact through sexual activity has been associated with the spread of monkeypox virus (MPXV) in the ongoing, global 2022 epidemic. However, it remains unclear whether MPXV replicates in the testes or is transmitted via semen to produce an active infection. We carried out a retrospective analysis of MPXV-infected crab-eating macaque archival tissue samples from acute and convalescent phases of infection of clade I or clade II MPXV using immunostaining and RNA in situ hybridization. We detected MPXV in interstitial cells and seminiferous tubules of testes as well as epididymal lumina, which are the sites of sperm production and maturation. We also detected inflammation and necrosis during the acute phase of the disease by histological analysis. Finally, we found that MPXV was cleared from most organs during convalescence, including healed skin lesions, but could be detected for up to 37 d post-exposure in the testes of convalescent macaques. Our findings highlight the potential for sexual transmission of MPXV in humans.

Indexed as

Monkeypox virusMpox, MonkeypoxAnimalsDisease Models, AnimalHumansMacaca fascicularisMaleRetrospective StudiesSemenSurvivorsTestis

Identifiers

PMID36253513
OpenAlexW4306412241

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.